HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Lyu, L.-C. Articles by Schaefer, E. J Search for Related Content PubMed PubMed Citation Articles by Lyu, L.-C. Articles by Schaefer, E. J Agricola Articles by Lyu, L.-C. Articles by Schaefer, E. J

Association of sex, adiposity, and diet with HDL subclasses in middle-aged Chinese^1,2,3

¹ From the Graduate Program of Nutrition, National Taiwan Normal University, Taipei, Taiwan, Republic of China; the Department of Public Health, Taipei Medical College, Taipei, Taiwan, Republic of China; and the Lipid Research Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston.

Background: There is limited information regarding the associations of lifestyle factors and sex with HDL subclasses containing apolipoprotein (apo) A-I (Lp A-I) and both apo A-I and apo A-II (Lp A-I:A-II).

Objective: We sought to examine the relations between 2 major HDL subclasses and sex, menopausal status, nutrient intakes, and adiposity.

Design: We conducted interviews and measured blood variables in 409 government employees aged 40–59 y in Taiwan.

Results: Women (n = 203) had significantly higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did men (n = 206). Postmenopausal women (n = 72) had higher concentrations of HDL cholesterol, Lp A-I, and Lp A-I:A-II than did premenopausal women (n = 131). Body mass index and waist-to-hip ratio were strong predictors of and exerted an independent additive effect on Lp A-I concentrations in both men and women. However, body adiposity was associated with Lp A-I:A-II concentrations only in men. Waist-to-hip ratio was an independent determinant of Lp A-I but not of Lp A-I:A-II in men and postmenopausal women after adjustment for age, body mass index, smoking, and diet. Although there were relatively weak associations between dietary factors and both HDL subclasses (r = 0.01–0.26) in men and women according to bivariate analyses, multiple regression models showed that total fat, saturated fat, and cholesterol intakes were significantly correlated with HDL cholesterol and both Lp A-I and Lp A-I:A-II in men, but not in women.

Conclusion: Our data suggest that body adiposity and dietary fat consumption affect 2 major HDL subclasses differently depending on subject sex and menopausal status.

Key Words: Cardiovascular disease • HDL cholesterol • high-density-lipoprotein cholesterol • HDL subclasses • body mass index • BMI • waist-to-hip ratio • adiposity • body fat • diet • dietary fat • sex • menopausal status • Chinese population • Taiwan

This article has been cited by other articles:

				Y. Ruixing, F. Qiming, Y. Dezhai, L. Shuquan, L. Weixiong, P. Shangling, W. Hai, Y. Yongzhong, H. Feng, and Q. Shuming Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations J. Lipid Res., December 1, 2007; 48(12): 2673 - 2681. [Abstract] [Full Text] [PDF]