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American Journal of Clinical Nutrition, Vol. 74, No. 4, 418-425, October 2001
© 2001 American Society for Clinical Nutrition

Review Article

Flavonoids: a review of probable mechanisms of action and potential applications1,2,3

Robert J Nijveldt, Els van Nood, Danny EC van Hoorn, Petra G Boelens, Klaske van Norren and Paul AM van Leeuwen

1 From the Department of Surgery, Vrije Universiteit Medical Center, Amsterdam, and Numico Research, Wageningen, Netherlands.

The aim of this review, a summary of the putative biological actions of flavonoids, was to obtain a further understanding of the reported beneficial health effects of these substances. Flavonoids occur naturally in fruit, vegetables, and beverages such as tea and wine. Research in the field of flavonoids has increased since the discovery of the French paradox,ie, the low cardiovascular mortality rate observed inMediterranean populations in association with red wine consumptionand a high saturated fat intake. Several other potentialbeneficial properties of flavonoids have since been ascertained.We review the different groups of known flavonoids, the probablemechanisms by which they act, and the potential clinicalapplications of these fascinating natural substances.

Key Words: Flavonoids • bioflavonoids • antioxidants • French paradox • review • polyphenols




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