| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
1 From the Department of Nutritional Sciences, University of Connecticut, Storrs, and the Departamento de Investigación y Posgrado en Alimentos, Universidad de Sonora, México.
Background: The primary mechanisms by which soluble fiber lowers plasma cholesterol are well known. However, specific effects of fiber on lipoprotein metabolism and how sex and hormonal status influence these effects are not well defined.
Objective: The effects of a psyllium supplement in men, premenopausal women, and postmenopausal women were examined to determine the mechanisms by which psyllium lowers plasma LDL-cholesterol concentrations and affects lipoprotein remodeling in the intravascular compartment.
Design: We designed a crossover trial in which 24 men, 23 premenopausal women, and 21 postmenopausal women were randomly assigned for 30 d to a fiber supplement (15 g psyllium/d) or a control. Plasma lipids and cholesteryl ester transfer protein and lecithin-cholesterol acyltransferase (phosphatidylcholine-sterol O-acyltransferase) activities were measured after each treatment.
Results: When compared with the control, psyllium intake lowered plasma LDL-cholesterol concentrations by 7–9% (P < 0.0001) without affecting plasma HDL-cholesterol concentrations. An interactive effect between fiber and sex and hormonal status was observed for plasma triacylglycerol. Psyllium supplementation significantly lowered plasma triacylglycerol concentrations in men by 17% and raised triacylglycerol concentrations in postmenopausal women by 16% (P < 0.01). The dietary treatment did not significantly affect plasma triacylglycerol in premenopausal women. Lecithin-cholesterol acyltransferase was unaffected by psyllium intake whereas cholesteryl ester transfer protein activity was 18% lower after psyllium supplementation than after the control treatment (P < 0.0001).
Conclusions: This trial showed that the psyllium-induced responses to plasma lipids were associated with sex and hormonal status and that psyllium, through its action in the intestinal lumen, indirectly affected the intravascular processing of lipoproteins.
Key Words: Cholesteryl ester transfer protein • lecithin-cholesterol acyltransferase • dietary soluble fiber • sex • hormonal status • lipoproteins • plasma cholesterol • plasma triacylglycerol • psyllium • men • premenopausal women • postmenopausal women
This article has been cited by other articles:
|
|
 |
|
  S. Shrestha, H. C. Freake, M. M. McGrane, J. S. Volek, and M. L. Fernandez A Combination of Psyllium and Plant Sterols Alters Lipoprotein Metabolism in Hypercholesterolemic Subjects by Modifying the Intravascular Processing of Lipoproteins and Increasing LDL Uptake J. Nutr., May 1, 2007; 137(5): 1165 - 1170. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Shrestha, J. S. Volek, J. Udani, R. J.Wood, C. M. Greene, D. Aggarwal, J. H. Contois, B. Kavoussi, and M. L. Fernandez A Combination Therapy Including Psyllium and Plant Sterols Lowers LDL Cholesterol by Modifying Lipoprotein Metabolism in Hypercholesterolemic Individuals J. Nutr., October 1, 2006; 136(10): 2492 - 2497. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Zern, R. J. Wood, C. Greene, K. L. West, Y. Liu, D. Aggarwal, N. S. Shachter, and M. L. Fernandez Grape Polyphenols Exert a Cardioprotective Effect in Pre- and Postmenopausal Women by Lowering Plasma Lipids and Reducing Oxidative Stress J. Nutr., August 1, 2005; 135(8): 1911 - 1917. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Ballesteros, R. M. Cabrera, M. del Socorro Saucedo, and M. L. Fernandez Dietary cholesterol does not increase biomarkers for chronic disease in a pediatric population from northern Mexico Am. J. Clinical Nutrition, October 1, 2004; 80(4): 855 - 861. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Herron, S. Vega-Lopez, K. Conde, T. Ramjiganesh, N. S. Shachter, and M. L. Fernandez Men Classified as Hypo- or Hyperresponders to Dietary Cholesterol Feeding Exhibit Differences in Lipoprotein Metabolism J. Nutr., April 1, 2003; 133(4): 1036 - 1042. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Vega-Lopez, H. C. Freake, and M. L. Fernandez Sex and Hormonal Status Modulate the Effects of Psyllium on Plasma Lipids and Monocyte Gene Expression in Humans J. Nutr., January 1, 2003; 133(1): 67 - 70. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Herron, S. Vega-Lopez, K. Conde, T. Ramjiganesh, S. Roy, N. S. Shachter, and M. L. Fernandez Pre-Menopausal Women, Classified as Hypo- or Hyper-Responders, do not Alter their LDL/HDL Ratio Following a High Dietary Cholesterol Challenge J. Am. Coll. Nutr., June 1, 2002; 21(3): 250 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Romero, K. L. West, T. Zern, and M. L. Fernandez The Seeds from Plantago ovata Lower Plasma Lipids by Altering Hepatic and Bile Acid Metabolism in Guinea Pigs J. Nutr., June 1, 2002; 132(6): 1194 - 1198. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
