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Original Research Communication |
1 From the Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, the School of Medicine, Boston University; the Department of Epidemiology, the School of Public Health, University of North Carolina at Chapel Hill; the Department of Laboratory Medicine and Pathology, Fairview-University Medical Center, Minneapolis; the Division of Epidemiology, University of Minnesota, Minneapolis; the Department of Cardiovascular Genetics, University of Utah, Salt Lake City; and the Division of Biostatistics, Washington University, St Louis.
Background: Epidemiologic studies suggest that a higher consumption of eicosapentaenoic acid and docosahexaenoic acid is associated with a reduced risk of cardiovascular disease. Studies in humans and animals also reported an inverse association between 
-linolenic acid and cardiovascular disease morbidity and mortality.
Objective: We examined the relation between dietary linolenic acid and prevalent coronary artery disease (CAD).
Design: We studied 4584 participants with a mean (±SD) age of 52.1 ± 13.7 y in the National Heart, Lung, and Blood Institute Family Heart Study in a cross-sectional design. Participants' diets were assessed with a semiquantitative food-frequency questionnaire. For each sex, we created age- and energy-adjusted quintiles of linolenic acid, and we used logistic regression to estimate prevalent odds ratios for CAD.
Results: From the lowest to the highest quintile of linolenic acid, the prevalence odds ratios of CAD were 1.0, 0.77, 0.61, 0.58, and 0.60 for the men (P for trend = 0.012) and 1.0, 0.57, 0.52, 0.30, and 0.42 for the women (P for trend = 0.014) after adjustment for age, linoleic acid, and anthropometric, lifestyle, and metabolic factors. Linoleic acid was also inversely related to the prevalence odds ratios of CAD in the multivariate model (0.60 and 0.61 in the second and third tertiles, respectively) after adjustment for linolenic acid. The combined effect of linoleic and linolenic acids was stronger than the individual effects of either fatty acid.
Conclusions: A higher intake of either linolenic or linoleic acid was inversely related to the prevalence odds ratio of CAD. The 2 fatty acids had synergistic effects on the prevalence odds ratio of CAD.
Key Words: Linolenic acid • linoleic acid • n-3 fatty acids • n-6 fatty acids • diet • coronary artery disease • food-frequency questionnaire • National Heart • Lung • Blood Institute Family Heart Study
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