AJCN North Carolina Research Campus
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Robertson, M D.
Right arrow Articles by Rumsey, R D. E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Robertson, M D.
Right arrow Articles by Rumsey, R D. E
Agricola
Right arrow Articles by Robertson, M D.
Right arrow Articles by Rumsey, R D. E
American Journal of Clinical Nutrition, Vol. 75, No. 3, 505-510, March 2002
© 2002 American Society for Clinical Nutrition

Original Research Communication

Extended effects of evening meal carbohydrate-to-fat ratio on fasting and postprandial substrate metabolism1,2,3

M Denise Robertson, R Alex Henderson, Gunn E Vist and R David E Rumsey

1 From the Oxford Centre for Diabetes, Endocrinlogy, and Metabolism, the Nuffield Department of Clinical Medicine, the University of Oxford, Oxford, United Kingdom (MDR), and the Department of Biomedical Science, the University of Sheffield, Sheffield, United Kingdom (RAH, GEV, and DER).

Background: High-fat and high-carbohydrate diets lead to insulin resistance, gastrointestinal adaptation, and high plasma triacylglycerol concentrations. It is unclear, however, how rapidly these changes occur.

Objective: We sought to determine the effects of both high-fat and high-carbohydrate evening meals on parameters of insulin resistance, hypertriglyceridemia, and gastrointestinal hormones.

Design: Twelve healthy men were studied on 4 separate occasions. On 2 occasions, the subjects received a high-fat evening meal (62% of energy from fat) and on the other 2 occasions the subjects received a low-fat evening meal (16% of energy from fat). The morning after each meal the subjects were administered either an oral-fat-tolerance test or an oral-glucose-tolerance test. Plasma samples were analyzed for glucose, insulin, fatty acids, 3-hydroxybutyrate, triacylglycerol, pancreatic polypeptide, peptide YY, and cholecystokinin. Postchallenge data were analyzed by two-way analysis of variance with interaction and fasting concentrations analyzed by repeated-measures analysis of variance.

Results: Fasting plasma concentrations of triacylglycerol were significantly elevated 12 h after each evening meal, but fatty acid and 3-hydroxybutyrate concentrations were reduced. No effects on glucose or insulin concentrations were detected. The high-fat evening meals elevated plasma cholecystokinin concentrations, reduced fasting concentrations of pancreatic polypeptide, and had no significant effect on peptide YY concentrations. The ratio of fat to carbohydrate in the evening meal produced significant effects on plasma triacylglycerol and fatty acids during both the oral-fat-tolerance and oral-glucose-tolerance tests.

Conclusions: The present study showed that the effects of high-fat and high-carbohydrate evening meals persist at least overnight and suggests that knowledge of recent dietary history is essential to the effective design of metabolic studies.

Key Words: Evening meal • high-carbohydrate meal • high-fat meal • oral glucose tolerance test • oral fat tolerance test • triacylglycerol




This article has been cited by other articles:


Home page
 Am. J. Clin. Nutr.Home page
R. Roberts, A. S Bickerton, B. A Fielding, E. E Blaak, A. J Wagenmakers, M. F-F Chong, M. Gilbert, F. Karpe, and K. N Frayn
Reduced oxidation of dietary fat after a short term high-carbohydrate diet
Am. J. Clinical Nutrition, April 1, 2008; 87(4): 824 - 831.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
T. M. Wolever, J. C Brand-Miller, J. Abernethy, A. Astrup, F. Atkinson, M. Axelsen, I. Bjorck, F. Brighenti, R. Brown, A. Brynes, et al.
Measuring the glycemic index of foods: interlaboratory study
Am. J. Clinical Nutrition, January 1, 2008; 87(1): 247S - 257S.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
F. Magkos, B. W. Patterson, and B. Mittendorfer
Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics
J. Lipid Res., May 1, 2007; 48(5): 1204 - 1211.
[Abstract] [Full Text] [PDF]

Home page
 J. Lipid Res.Home page
E. J. Parks and M. K. Hellerstein
Thematic review series: Patient-Oriented Research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques
J. Lipid Res., August 1, 2006; 47(8): 1651 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. D. Oakes, P. Thalen, T. Hultstrand, S. Jacinto, G. Camejo, B. Wallin, and B. Ljung
Tesaglitazar, a dual PPAR{alpha}/{gamma} agonist, ameliorates glucose and lipid intolerance in obese Zucker rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R938 - R946.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M D. Robertson, A. S Bickerton, A L. Dennis, H. Vidal, and K. N Frayn
Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism
Am. J. Clinical Nutrition, September 1, 2005; 82(3): 559 - 567.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
M. D. Robertson, A. S. T. Bickerton, A. L. Dennis, H. Vidal, D. P. Jewell, and K. N. Frayn
Enhanced Metabolic Cycling in Subjects after Colonic Resection for Ulcerative Colitis
J. Clin. Endocrinol. Metab., May 1, 2005; 90(5): 2747 - 2754.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
M. T Timlin and E. J Parks
Temporal pattern of de novo lipogenesis in the postprandial state in healthy men
Am. J. Clinical Nutrition, January 1, 2005; 81(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. W. Zderic, S. Schenk, C. J. Davidson, L. O. Byerley, and E. F. Coyle
Manipulation of dietary carbohydrate and muscle glycogen affects glucose uptake during exercise when fat oxidation is impaired by {beta}-adrenergic blockade
Am J Physiol Endocrinol Metab, December 1, 2004; 287(6): E1195 - E1201.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Coll. Nutr.Home page
J. S. Volek, M. J. Sharman, A. L. Gomez, C. DiPasquale, M. Roti, A. Pumerantz, and W. J. Kraemer
Comparison of a Very Low-Carbohydrate and Low-Fat Diet on Fasting Lipids, LDL Subclasses, Insulin Resistance, and Postprandial Lipemic Responses in Overweight Women
J. Am. Coll. Nutr., April 1, 2004; 23(2): 177 - 184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
T. W. Zderic, C. J. Davidson, S. Schenk, L. O. Byerley, and E. F. Coyle
High-fat diet elevates resting intramuscular triglyceride concentration and whole body lipolysis during exercise
Am J Physiol Endocrinol Metab, February 1, 2004; 286(2): E217 - E225.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Schenk, C. J Davidson, T. W Zderic, L. O Byerley, and E. F Coyle
Different glycemic indexes of breakfast cereals are not due to glucose entry into blood but to glucose removal by tissue
Am. J. Clinical Nutrition, October 1, 2003; 78(4): 742 - 748.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. K Fried and S. P Rao
Sugars, hypertriglyceridemia, and cardiovascular disease
Am. J. Clinical Nutrition, October 1, 2003; 78(4): 873S - 880.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2002 by The American Society for Nutrition