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Original Research Communication |
1 From the Gastrointestinal Laboratory, The Rayne Institute, St Thomas' Hospital, London (RJ, SHCA, and RPHT); the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston (KLT); the Department of Nutrition and Dietetics, King's College London (HE and JJP); and the Harvard Medical School Division on Aging, HRCA Research and Training Institute, Boston (DPK).
Background: Increasing evidence suggests that silicon is important in bone formation. The main source of silicon for humans is the diet, but the bioavailability of silicon from solid foods is not well understood.
Objective: We estimated the dietary intake of silicon by adults, separately for men and women and for different age groups. Foods that were major contributors to silicon intake were identified. We then estimated the gastrointestinal uptake of silicon from major food sources and studied how uptake correlated with the silicon contents of the foods.
Design: Silicon intakes were determined in cohorts from the original Framingham Study and the Framingham Offspring Study by using a 126-item food-frequency questionnaire. Gastrointestinal uptake of silicon from foods was estimated in 3–8 healthy subjects by using urinary silicon excretion as a surrogate measure of silicon uptake.
Results: Mean silicon intakes in men (30 and 33 mg/d in the original Framingham and Framingham Offspring cohorts, respectively) were significantly higher than those in women (24 and 25 mg/d in the 2 cohorts, respectively; P = 0.0001). Silicon intake decreased with age (P < 0.001, adjusted for sex). The major food sources were beer and bananas in men and bananas and string beans in women. Silicon was readily available from foods; a mean of 41% of the ingested silicon was excreted in urine. The silicon content of the foods consumed was significantly correlated with urinary silicon excretion (P = 0.019).
Conclusions: Solid foods are a major source of available silicon. The association between dietary silicon intake and bone health should now be investigated.
Key Words: Silicon • orthosilicic acid • phytolithic silica • silicon intake • gastrointestinal absorption • bioavailability • cohort study • diet • nutrition • bone formation
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