HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Singhal, A. Articles by Serjeant, G. Search for Related Content PubMed PubMed Citation Articles by Singhal, A. Articles by Serjeant, G. Agricola Articles by Singhal, A. Articles by Serjeant, G.

Energy intake and resting metabolic rate in preschool Jamaican children with homozygous sickle cell disease^1,2

¹ From the MRC Childhood Nutrition Research Center, Institute of Child Health, London (AS); the Cooperative Extension Service and the Department of Nutritional Sciences, Oklahoma State University, Stillwater (SP); and the Medical Research Council Laboratories (Jamaica), University of the West Indies, Kingston, Jamaica (AS, SP, LL, and GS).

Background: A relative energy deficiency consequent to a high resting metabolic rate (RMR) may contribute to growth impairment in persons with homozygous (SS genotype) sickle cell disease (SCD). The growth deficit in SCD emerges at an early age, but few studies have addressed the adequacy of energy intake relative to RMR in young children.

Objective: Our objective was to test the hypothesis that energy intake relative to RMR is lower in children with SCD than in control subjects.

Design: The dietary intake of 41 children with SCD and 31 control subjects with a normal hemoglobin genotype (AA) aged 3–6 y was assessed by weighing all food consumed during 3 d. RMR was determined with the use of indirect calorimetry.

Results: The RMR in the children with SCD ( ± SD: 5.47 ± 0.93 MJ/d) was higher than that in the control subjects (5.19 ± 1.3 MJ/d) after adjustment for sex and weight (P = 0.04). Energy intake did not differ significantly between the 2 genotype groups. The ratio of energy intake to RMR was lower in the children with SCD ( ± SD: 1.13 ± 0.33) than in the control subjects (1.35 ± 0.38) after adjustment for sex and weight (P = 0.005).

Conclusions: Prepubertal children with SCD fail to compensate for their higher RMR by increasing their energy intake. This observation is consistent with a hypothesis of a relative energy deficiency in SCD.

Key Words: Energy intake • resting metabolic rate • sickle cell disease • children • Jamaica • weighed food intake

This article has been cited by other articles:

				D. R. Archer, J. K. Stiles, G. W. Newman, A. Quarshie, L. L. Hsu, P. Sayavongsa, J. Perry, E. M. Jackson, and J. M. Hibbert C-Reactive Protein and Interleukin-6 Are Decreased in Transgenic Sickle Cell Mice Fed a High Protein Diet J. Nutr., June 1, 2008; 138(6): 1148 - 1152. [Abstract] [Full Text] [PDF]

				J. Thompson, M. Reid, I. Hambleton, and G. R. Serjeant Albuminuria and Renal Function in Homozygous Sickle Cell Disease: Observations From a Cohort Study Arch Intern Med, April 9, 2007; 167(7): 701 - 708. [Abstract] [Full Text] [PDF]

				M. Reid, A. Badaloo, T. Forrester, and F. Jahoor In vivo rates of erythrocyte glutathione synthesis in adults with sickle cell disease Am J Physiol Endocrinol Metab, July 1, 2006; 291(1): E73 - E79. [Abstract] [Full Text] [PDF]

				J. M. Hibbert, L. L. Hsu, S. J. Bhathena, I. Irune, B. Sarfo, M. S. Creary, B. E. Gee, A. I. Mohamed, I. D. Buchanan, A. Al-Mahmoud, et al. Proinflammatory Cytokines and the Hypermetabolism of Children with Sickle Cell Disease Experimental Biology and Medicine, January 1, 2005; 230(1): 68 - 74. [Abstract] [Full Text] [PDF]