| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
1 From the Departments of Pulmonology (HRG, MPKJE, EFMW, and AMWJS), Anatomy and Embryology (HVM and PJVD), and Physiology (GJVDV), University of Maastricht, Maastricht, Netherlands.
Background: Although the loss of peripheral muscle mass has been shown convincingly in chronic obstructive pulmonary disease (COPD), the underlying pathogenesis remains unclear.
Objective: The aim of the present study was to determine the relations between skeletal muscle fiber types, fiber cross-sectional area (CSA), enzyme activities, and fat-free mass (FFM) in patients with COPD and in control subjects.
Design: In 15 patients with COPD and 15 healthy, age-matched control subjects, FFM was determined by dual-energy X-ray absorptiometry and bioelectrical impedance analysis. In biopsy specimens from the vastus lateralis fiber types, fiber CSA and activities of cytochrome oxidase (EC 1.9.3.1), succinate dehydrogenase (EC 1.3.99.1), and glycogen phosphorylase (EC 2.4.1.1) were examined immunohistochemically and histochemically.
Results: Compared with control subjects, patients with COPD had less FFM (49 compared with 59 kg, P = 0.030) and lower mean fiber CSA (3839 compared with 4647 µm2, P = 0.037). A strong correlation (r = 0.87, P < 0.001) was observed between the FFM measured by bioelectrical impedance analysis and mean fiber CSA in patients with COPD. Within fiber-type categories the mean CSA of only the IIA/IIX and IIX fiber types was lower in patients than in control subjects [3358 compared with 4428 µm2 (P = 0.022) and 2566 compared with 4248 µm2 (P = 0.003), respectively]. In COPD, 20% of the type IIX fibers lacked stainable activities of cytochrome oxidase, succinate dehydrogenase, and glycogen phosphorylase, and this proportion correlated negatively with type IIX fiber CSA (r = -0.65, P = 0.012).
Conclusions: Muscle fiber atrophy occurs in the vastus lateralis in patients with COPD and contributes to the loss of muscle mass in COPD. Atrophy is specific to fiber types IIA/IIX and IIX and is associated with a disturbed metabolic capacity.
Key Words: Skeletal muscle mass • fiber atrophy • chronic obstructive pulmonary disease • fiber types • energy metabolism • cross-sectional area
This article has been cited by other articles:
|
|
 |
|
  M. J. H. Sillen, C. M. Speksnijder, R.-M. A. Eterman, P. P. Janssen, S. S. Wagers, E. F. M. Wouters, N. H. M. K. Uszko-Lencer, and M. A. Spruit Effects of Neuromuscular Electrical Stimulation of Muscles of Ambulation in Patients With Chronic Heart Failure or COPD: A Systematic Review of the English-Language Literature Chest, July 1, 2009; 136(1): 44 - 61. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Jolley and J. Moxham A physiological model of patient-reported breathlessness during daily activities in COPD Eur. Respir. Rev., June 1, 2009; 18(112): 66 - 79. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Gosker, R. C. J. Langen, K. R. Bracke, G. F. Joos, G. G. Brusselle, C. Steele, K. A. Ward, E. F. M. Wouters, and A. M. W. J. Schols Extrapulmonary Manifestations of Chronic Obstructive Pulmonary Disease in a Mouse Model of Chronic Cigarette Smoke Exposure Am. J. Respir. Cell Mol. Biol., June 1, 2009; 40(6): 710 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. J. Green, M. E. Burnett, C. L. D'Arsigny, D. E. O'Donnell, J. Ouyang, and K. A. Webb Altered metabolic and transporter characteristics of vastus lateralis in chronic obstructive pulmonary disease J Appl Physiol, September 1, 2008; 105(3): 879 - 886. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. M. Chatila, B. M. Thomashow, O. A. Minai, G. J. Criner, and B. J. Make Comorbidities in Chronic Obstructive Pulmonary Disease Proceedings of the ATS, May 1, 2008; 5(4): 549 - 555. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. D. Calvert, S. J. Singh, P. L. Greenhaff, M. D. Morgan, and M. C. Steiner The plasma ammonia response to cycle exercise in COPD Eur. Respir. J., April 1, 2008; 31(4): 751 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R Gosker, M. P Zeegers, E. F M Wouters, and A. M W J Schols Muscle fibre type shifting in the vastus lateralis of patients with COPD is associated with disease severity: a systematic review and meta-analysis Thorax, November 1, 2007; 62(11): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Remels, P. Schrauwen, R. Broekhuizen, J. Willems, S. Kersten, H. R. Gosker, and A. M. Schols Peroxisome proliferator-activated receptor expression is reduced in skeletal muscle in COPD Eur. Respir. J., August 1, 2007; 30(2): 245 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Nici, C. Donner, E. Wouters, R. Zuwallack, N. Ambrosino, J. Bourbeau, M. Carone, B. Celli, M. Engelen, B. Fahy, et al. American thoracic society/european respiratory society statement on pulmonary rehabilitation. Am. J. Respir. Crit. Care Med., June 15, 2006; 173(12): 1390 - 1413. [Full Text] [PDF]
|
|
|
|
|
|
E. F. M. Wouters Muscle Wasting in Chronic Obstructive Pulmonary Disease: To Bother and to Measure! Am. J. Respir. Crit. Care Med., January 1, 2006; 173(1): 4 - 5. [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Schols, R. Broekhuizen, C. A Weling-Scheepers, and E. F Wouters Body composition and mortality in chronic obstructive pulmonary disease Am. J. Clinical Nutrition, July 1, 2005; 82(1): 53 - 59. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Troosters, R. Casaburi, R. Gosselink, and M. Decramer Pulmonary Rehabilitation in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., July 1, 2005; 172(1): 19 - 38. [Full Text] [PDF]
|
|
|
|
|
|
D. Saey, A. Michaud, A. Couillard, C. H. Cote, M. J. Mador, P. LeBlanc, J. Jobin, and F. Maltais Contractile Fatigue, Muscle Morphometry, and Blood Lactate in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., May 15, 2005; 171(10): 1109 - 1115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. E. Franssen, R. Broekhuizen, P. P. Janssen, E. F. M. Wouters, and A. M. W. J. Schols Effects of Whole-Body Exercise Training on Body Composition and Functional Capacity in Normal-Weight Patients With COPD Chest, June 1, 2004; 125(6): 2021 - 2028. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R.T. Jagoe and M.P.K.J. Engelen Muscle wasting and changes in muscle protein metabolism in chronic obstructive pulmonary disease Eur. Respir. J., November 2, 2003; 22(46_suppl): 52s - 63s. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.R. Gosker, B. Kubat, G. Schaart, G.J. van der Vusse, E.F.M. Wouters, and A.M.W.J. Schols Myopathological features in skeletal muscle of patients with chronic obstructive pulmonary disease Eur. Respir. J., August 1, 2003; 22(2): 280 - 285. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W D-C Man, M G G Soliman, D Nikoletou, M L Harris, G F Rafferty, N Mustfa, M I Polkey, and J Moxham Non-volitional assessment of skeletal muscle strength in patients with chronic obstructive pulmonary disease Thorax, August 1, 2003; 58(8): 665 - 669. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H.R. Gosker, P. Schrauwen, M.K.C. Hesselink, G. Schaart, G.J. van der Vusse, E.F.M. Wouters, and A.M.W.J. Schols Uncoupling protein-3 content is decreased in peripheral skeletal muscle of patients with COPD Eur. Respir. J., July 1, 2003; 22(1): 88 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Y. Sue Peripheral Muscle Dysfunction in Patients With COPD: Comparing Apples to Apples? Chest, July 1, 2003; 124(1): 1 - 4. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
