| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
production by peripheral blood mononuclear cells in healthy men is associated with polymorphisms in genes that influence tumor necrosis factor production1,2,3
1 From the Institute of Human Nutrition, School of Medicine, and the Biochemistry and Molecular Biology Division, School of Biological Sciences, University of Southampton, Southampton, United Kingdom (RFG, GO, OM, SH, JME, and PCC), and the Histocompatibility and Immunogenetics Laboratory, Southampton University Hospitals Trust, Southampton, United Kingdom (SJT and WMH).
Background: Tumor necrosis factor 
(TNF-) mediates inflammation. High TNF- production has adverse effects during disease. Polymorphisms in the TNF- and lymphotoxin genes influence TNF- production. Fish oil suppresses TNF- production and has variable antiinflammatory effects on disease.
Objective: We examined the relation between TNF- and lymphotoxin genotypes and the ability of dietary fish oil to suppress TNF- production by peripheral blood mononuclear cells (PBMCs) in healthy men.
Design: Polymorphisms in the TNF- (TNF*1 and TNF*2) and lymphotoxin (TNFB*1 and TNFB*2) genes were determined in 111 healthy young men. TNF- production by endotoxin-stimulated PBMCs was measured before and 12 wk after dietary supplementation with fish oil (6 g/d).
Results: Homozygosity for TNFB*2 was 2.5 times more frequent in the highest than in the lowest tertile of inherent TNF- production. The percentage of subjects in whom fish oil suppressed TNF- production was lowest (22%) in the lowest tertile and doubled with each ascending tertile. In the highest and lowest tertiles, mean TNF- production decreased by 43% (P < 0.05) and increased by 160% (P < 0.05), respectively. In the lowest tertile of TNF- production, only TNFB*1/TNFB*2 heterozygous subjects were responsive to the suppressive effect of fish oil. In the middle tertile, this genotype was 6 times more frequent than the other lymphotoxin genotypes among responsive individuals. In the highest tertile, responsiveness to fish oil appeared unrelated to lymphotoxin genotype.
Conclusion: The ability of fish oil to decrease TNF- production is influenced by inherent TNF- production and by polymorphisms in the TNF- and lymphotoxin genes.
Key Words: TNF- production • lymphotoxin • genotype • fish oil • inflammation • healthy men • peripheral blood mononuclear cells • TNF*1 • TNF*2 • TNFB*1 • TNFB*2
This article has been cited by other articles:
|
|
 |
|
  J. W. Fetterman Jr. and M. M. Zdanowicz Therapeutic potential of n-3 polyunsaturated fatty acids in disease Am. J. Health Syst. Pharm., July 1, 2009; 66(13): 1169 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. S. Kim, M. R. Young, G. Bobe, N. H. Colburn, and J. A. Milner Bioactive Food Components, Inflammatory Targets, and Cancer Prevention Cancer Prevention Research, March 1, 2009; 2(3): 200 - 208. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. L.C. Chapple Potential Mechanisms Underpinning the Nutritional Modulation of Periodontal Inflammation J Am Dent Assoc, February 1, 2009; 140(2): 178 - 184. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J Caslake, E. A Miles, B. M Kofler, G. Lietz, P. Curtis, C. K Armah, A. C Kimber, J. P Grew, L. Farrell, J. Stannard, et al. Effect of sex and genotype on cardiovascular biomarker response to fish oils: the FINGEN Study Am. J. Clinical Nutrition, September 1, 2008; 88(3): 618 - 629. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. J.A. Jenkins, A. R. Josse, P. Dorian, M. L. Burr, R. LaBelle Trangmar, C. W.C. Kendall, and S. C. Cunnane Heterogeneity in Randomized Controlled Trials of Long Chain (Fish) Omega-3 Fatty Acids in Restenosis, Secondary Prevention and Ventricular Arrhythmias J. Am. Coll. Nutr., June 1, 2008; 27(3): 367 - 378. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N.-T. Luu, J. Madden, P. C. Calder, R. F. Grimble, C. P. Shearman, T. Chan, N. Dastur, W. M. Howell, G. E. Rainger, and G. B. Nash Dietary Supplementation with Fish Oil Modifies the Ability of Human Monocytes to Induce an Inflammatory Response J. Nutr., December 1, 2007; 137(12): 2769 - 2774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Fontaine-Bisson, T. M. Wolever, J.-L. Chiasson, R. Rabasa-Lhoret, P. Maheux, R. G Josse, L. A Leiter, N W. Rodger, E. A Ryan, P. W Connelly, et al. Genetic polymorphisms of tumor necrosis factor-{alpha} modify the association between dietary polyunsaturated fatty acids and fasting HDL-cholesterol and apo A-I concentrations Am. J. Clinical Nutrition, September 1, 2007; 86(3): 768 - 774. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. M. Howell and M. J. Rose-Zerilli Cytokine Gene Polymorphisms, Cancer Susceptibility, and Prognosis J. Nutr., January 1, 2007; 137(1): 194S - 199S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. S. Chapkin, L. A. Davidson, L. Ly, B. R. Weeks, J. R. Lupton, and D. N. McMurray Immunomodulatory Effects of (n-3) Fatty Acids: Putative Link to Inflammation and Colon Cancer J. Nutr., January 1, 2007; 137(1): 200S - 204S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. C.H. Fearon, M. D. Barber, A. G. Moses, S. H. Ahmedzai, G. S. Taylor, M. J. Tisdale, and G. D. Murray Double-Blind, Placebo-Controlled, Randomized Study of Eicosapentaenoic Acid Diester in Patients With Cancer Cachexia J. Clin. Oncol., July 20, 2006; 24(21): 3401 - 3407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. C Calder n-3 Polyunsaturated fatty acids, inflammation, and inflammatory diseases Am. J. Clinical Nutrition, June 1, 2006; 83(6): S1505 - 1519S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Watzl, S. E Kulling, J. Moseneder, S. W Barth, and A. Bub A 4-wk intervention with high intake of carotenoid-rich vegetables and fruit reduces plasma C-reactive protein in healthy, nonsmoking men Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1052 - 1058. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. A. Gassull, J. Mane, E. Pedrosa, and E. Cabre Macronutrients and Bioactive Molecules: Is There a Specific Role in the Management of Inflammatory Bowel Disease? JPEN J Parenter Enteral Nutr, July 1, 2005; 29(4_suppl): S179 - S183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R Broekhuizen, E F M Wouters, E C Creutzberg, C A P M Weling-Scheepers, and A M W J Schols Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease Thorax, May 1, 2005; 60(5): 376 - 382. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Mizock and S. J. DeMichele The Acute Respiratory Distress Syndrome: Role of Nutritional Modulation of Inflammation Through Dietary Lipids Nutr Clin Pract, December 1, 2004; 19(6): 563 - 574. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y.-Y. Fan, L. H. Ly, R. Barhoumi, D. N. McMurray, and R. S. Chapkin Dietary Docosahexaenoic Acid Suppresses T Cell Protein Kinase C{theta} Lipid Raft Recruitment and IL-2 Production J. Immunol., November 15, 2004; 173(10): 6151 - 6160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Karatay, T. Erdem, K. Yildirim, M. A. Melikoglu, M. Ugur, E. Cakir, F. Akcay, and K. Senel The effect of individualized diet challenges consisting of allergenic foods on TNF-{alpha} and IL-1{beta} levels in patients with rheumatoid arthritis Rheumatology, November 1, 2004; 43(11): 1429 - 1433. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. R. Bistrian Practical Recommendations for Immune-Enhancing Diets J. Nutr., October 1, 2004; 134(10): 2868S - 2872S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A.M.W.J. Schols Nutritional and metabolic modulation in chronic obstructive pulmonary disease management Eur. Respir. J., November 2, 2003; 22(46_suppl): 81s - 86s. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K C H Fearon, M F von Meyenfeldt, A G W Moses, R van Geenen, A Roy, D J Gouma, A Giacosa, A Van Gossum, J Bauer, M D Barber, et al. Effect of a protein and energy dense n-3 fatty acid enriched oral supplement on loss of weight and lean tissue in cancer cachexia: a randomised double blind trial Gut, October 1, 2003; 52(10): 1479 - 1486. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. O. McCarthy Rethinking Nutritional Support for Persons with Cancer Cachexia Biol Res Nurs, July 1, 2003; 5(1): 3 - 17. [Abstract] [PDF]
|
|
|
|
|
|
M. J James, V. M Ursin, and L. G Cleland Metabolism of stearidonic acid in human subjects: comparison with the metabolism of other n-3 fatty acids Am. J. Clinical Nutrition, May 1, 2003; 77(5): 1140 - 1145. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
