| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
1 From the Departments of Applied Chemistry and Microbiology (AMT and MM) and Animal Science (JMG), University of Helsinki; the Biomarker Laboratory, Department of Health and Functional Capacity, National Public Health Institute (AA and IS), Helsinki; the Department of Geriatrics, Uppsala University, Uppsala, Sweden (SB); and the Department of Animal Sciences, The Ohio State University, Wooster (DLP).
Background: Vaccenic acid (11-trans octadecenoic acid; VA), a major trans fatty acid in the fat of ruminants, is produced in the rumen and converted in tissues to rumenic acid (9-cis, 11-trans octadecenoic acid; RA), an isomer of conjugated linoleic acid, by 
9-desaturase. There are indications that this conversion also occurs in humans.
Objective: The aim of this controlled intervention was to study the conversion of VA to RA in humans after consumption of diets with increasing amounts of VA.
Design: Thirty healthy subjects consumed a baseline diet rich in oleic acid for 2 wk. The subjects were then divided into 3 groups (n = 10 per group) and provided a diet containing 1.5, 3.0, or 4.5 g VA/d for 9 d. All diets contained equal amounts of macronutrients and differed only in their fatty acid compositions. The fats were mixed into conventional foods, and nearly all food was provided during the study.
Results: The proportion of VA in serum total fatty acids increased 94%, 307%, and 620% above baseline with the 1.5-, 3.0-, and 4.5-g diets, respectively. This was associated with a linear increase in the proportion of RA. The conversion rate was 19% on average, with significant interindividual differences with all 3 intakes of VA. The urinary excretion of 8-iso-prostaglandin F2
increased in all groups (P < 0.001).
Conclusions: The results quantify the desaturation of VA to RA in humans. Conversion is likely to contribute significantly to the amount of RA available to the body, and dietary intakes of VA should thus be taken into account when predicting RA status.
Key Words: Vaccenic acid • rumenic acid • conjugated linoleic acid • trans fatty acids • endogenous synthesis • 9-desaturase • isoprostanes
This article has been cited by other articles:
|
|
 |
|
  M. L. Nelson, J. R. Busboom, C. F. Ross, and J. V. O'Fallon Effects of supplemental fat on growth performance and quality of beef from steers fed corn finishing diets J Anim Sci, April 1, 2008; 86(4): 936 - 948. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Shingfield, S. Ahvenjarvi, V. Toivonen, A. Vanhatalo, and P. Huhtanen Transfer of Absorbed cis-9, trans-11 Conjugated Linoleic Acid into Milk Is Biologically More Efficient than Endogenous Synthesis from Absorbed Vaccenic Acid in Lactating Cows J. Nutr., May 1, 2007; 137(5): 1154 - 1160. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H. Eckel, S. Borra, A. H. Lichtenstein, and S. Y. Yin-Piazza Understanding the Complexity of Trans Fatty Acid Reduction in the American Diet: American Heart Association Trans Fat Conference 2006: Report of the Trans Fat Conference Planning Group Circulation, April 24, 2007; 115(16): 2231 - 2246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. P. Bu, J. Q. Wang, T. R. Dhiman, and S. J. Liu Effectiveness of Oils Rich in Linoleic and Linolenic Acids to Enhance Conjugated Linoleic Acid in Milk from Dairy Cows J Dairy Sci, February 1, 2007; 90(2): 998 - 1007. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuhnt, A. Wagner, J. Kraft, S. Basu, and G. Jahreis Dietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humans. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 981 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Mosley, M. K. McGuire, J. E. Williams, and M. A. McGuire Cis-9, Trans-11 Conjugated Linoleic Acid Is Synthesized from Vaccenic Acid in Lactating Women J. Nutr., September 1, 2006; 136(9): 2297 - 2301. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Badinga and E. S. Greene Physiological Properties of Conjugated Linoleic Acid and Implications for Human Health Nutr Clin Pract, August 1, 2006; 21(4): 367 - 373. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Poirier, J. S. Shapiro, R. J. Kim, and M. A. Lazar Nutritional Supplementation With trans-10, cis-12-Conjugated Linoleic Acid Induces Inflammation of White Adipose Tissue Diabetes, June 1, 2006; 55(6): 1634 - 1641. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Kraft, L. Hanske, P. Mockel, S. Zimmermann, A. Hartl, J. K. G. Kramer, and G. Jahreis The Conversion Efficiency of trans-11 and trans-12 18:1 by {Delta}9-Desaturation Differs in Rats J. Nutr., May 1, 2006; 136(5): 1209 - 1214. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Tricon, G. C Burdge, E. L Jones, J. J Russell, S. El-Khazen, E. Moretti, W. L Hall, A. B Gerry, D. S Leake, R. F Grimble, et al. Effects of dairy products naturally enriched with cis-9,trans-11 conjugated linoleic acid on the blood lipid profile in healthy middle-aged men. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 744 - 753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Raff, T. Tholstrup, K. Sejrsen, E. M. Straarup, and N. Wiinberg Diets Rich in Conjugated Linoleic Acid and Vaccenic Acid Have No Effect on Blood Pressure and Isobaric Arterial Elasticity in Healthy Young Men J. Nutr., April 1, 2006; 136(4): 992 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. E. Mosley, B. Shafii{dagger}, P. J. Moate, and M. A. McGuire cis-9, trans-11 Conjugated Linoleic Acid Is Synthesized Directly from Vaccenic Acid in Lactating Dairy Cattle J. Nutr., March 1, 2006; 136(3): 570 - 575. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Tholstrup, M. Raff, S. Basu, P. Nonboe, K. Sejrsen, and E. M Straarup Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men Am. J. Clinical Nutrition, February 1, 2006; 83(2): 237 - 243. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A. Bell, J. M. Griinari, and J. J. Kennelly Effect of Safflower Oil, Flaxseed Oil, Monensin, and Vitamin E on Concentration of Conjugated Linoleic Acid in Bovine Milk Fat J Dairy Sci, February 1, 2006; 89(2): 733 - 748. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. L. Allred, T. R. Dhiman, C. P. Brennand, R. C. Khanal, D. J. McMahon, and N. D. Luchini Milk and Cheese from Cows Fed Calcium Salts of Palm and Fish Oil Alone or in Combination with Soybean Products J Dairy Sci, January 1, 2006; 89(1): 234 - 248. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Desroches, P Y. Chouinard, I. Galibois, L. Corneau, J. Delisle, B. Lamarche, P. Couture, and N. Bergeron Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men Am. J. Clinical Nutrition, August 1, 2005; 82(2): 309 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Lock, C. A. M. Horne, D. E. Bauman, and A. M. Salter Butter Naturally Enriched in Conjugated Linoleic Acid and Vaccenic Acid Alters Tissue Fatty Acids and Improves the Plasma Lipoprotein Profile in Cholesterol-Fed Hamsters J. Nutr., August 1, 2005; 135(8): 1934 - 1939. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. L. Ritzenthaler, M. K. McGuire, M. A. McGuire, T. D. Shultz, A. E. Koepp, L. O. Luedecke, T. W. Hanson, N. Dasgupta, and B. P. Chew Consumption of Conjugated Linoleic Acid (CLA) from CLA-Enriched Cheese Does Not Alter Milk Fat or Immunity in Lactating Women J. Nutr., March 1, 2005; 135(3): 422 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. Lynch, A. L. Lock, D. A. Dwyer, R. Noorbakhsh, D. M. Barbano, and D. E. Bauman Flavor and Stability of Pasteurized Milk with Elevated Levels of Conjugated Linoleic Acid and Vaccenic Acid J Dairy Sci, February 1, 2005; 88(2): 489 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. J. Scholljegerdes, B. W. Hess, G. E. Moss, D. L. Hixon, and D. C. Rule Influence of supplemental cracked high-linoleate or high-oleate safflower seeds on site and extent of digestion in beef cattle J Anim Sci, December 1, 2004; 82(12): 3577 - 3588. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Lock, B. A. Corl, D. M. Barbano, D. E. Bauman, and C. Ip The Anticarcinogenic Effect of trans-11 18:1 Is Dependent on Its Conversion to cis-9, trans-11 CLA by {Delta}9-Desaturase in Rats J. Nutr., October 1, 2004; 134(10): 2698 - 2704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. L. Palmquist, N. St-Pierre, and K. E. McClure Tissue Fatty Acid Profiles Can Be Used to Quantify Endogenous Rumenic Acid Synthesis in Lambs J. Nutr., September 1, 2004; 134(9): 2407 - 2414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Riserus, B. Vessby, J. Arnlov, and S. Basu Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men Am. J. Clinical Nutrition, August 1, 2004; 80(2): 279 - 283. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. A. Sauer, R. T. Dauchy, D. E. Blask, J. A. Krause, L. K. Davidson, E. M. Dauchy, K. J. Welham, and K. Coupland Conjugated Linoleic Acid Isomers and Trans Fatty Acids Inhibit Fatty Acid Transport in Hepatoma 7288CTC and Inguinal Fat Pads in Buffalo Rats J. Nutr., August 1, 2004; 134(8): 1989 - 1997. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. K. Kramer, C. Cruz-Hernandez, Z. Deng, J. Zhou, G. Jahreis, and M. E. Dugan Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1137S - 1145S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Lin, J. J. Loor, and J. H. Herbein Trans10,cis12-18:2 Is a More Potent Inhibitor of De Novo Fatty Acid Synthesis and Desaturation than cis9,trans11-18:2 in the Mammary Gland of Lactating Mice J. Nutr., June 1, 2004; 134(6): 1362 - 1368. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Corl, D. M. Barbano, D. E. Bauman, and C. Ip cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats J. Nutr., September 1, 2003; 133(9): 2893 - 2900. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
