| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
1 From the Departments of Nutritional Epidemiology (LEV, HAMB, and RAG) and Nutritional Physiology (AFMK), TNO Nutrition and Food Research, Zeist, Netherlands; the Dutch Dairy Foundation for Nutrition and Health, Utrecht, Netherlands (GJH); and the Department of Epidemiology, Maastricht University, Maastricht, Netherlands (PAVDB).
Background: Conjugated linoleic acid (CLA), which is present in milk products and meat from ruminants, appears to have anticarcinogenic activity against breast cancer in animal and in vitro experiments. To date, few epidemiologic data are available in humans.
Objective: This study evaluated the relation between intakes of CLA and other fatty acids and breast cancer incidence in the Netherlands Cohort Study.
Design: Intake data derived from a validated 150-item food-frequency questionnaire were linked to an existing database with analytic data on specific fatty acids in European foods (the TRANSFAIR study). With 6.3 y of follow-up and 941 incident cases of breast cancer, multivariate rate ratios and 95% CIs were calculated for energy-adjusted intakes of fatty acids and CLA-containing food groups (eg, butter, cheese, milk, other milk products, and meat).
Results: CLA intake showed a weak, positive relation with breast cancer incidence (rate ratio for highest compared with lowest quintile: 1.24, 95% CI: 0.91, 1.69; P for trend = 0.02). Statistically significant positive associations were found with total trans fatty acids and (borderline) with saturated fatty acids. Significant inverse associations were found with monounsaturated and cis unsaturated fatty acids, whereas total fat and energy intake of CLA-containing food groups were not related to breast cancer incidence.
Conclusion: The suggested anticarcinogenic property of CLA in animal and tissue culture models could not be confirmed in this epidemiologic study in humans.
Key Words: Cohort study • breast cancer • intake • fat • fatty acids • conjugated linoleic acid • trans fatty acids
This article has been cited by other articles:
|
|
 |
|
  V. Chajes, A. C. M. Thiebaut, M. Rotival, E. Gauthier, V. Maillard, M.-C. Boutron-Ruault, V. Joulin, G. M. Lenoir, and F. Clavel-Chapelon Association between Serum trans-Monounsaturated Fatty Acids and Breast Cancer Risk in the E3N-EPIC Study Am. J. Epidemiol., June 1, 2008; 167(11): 1312 - 1320. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Kelley, N. E. Hubbard, and K. L. Erickson Conjugated Linoleic Acid Isomers and Cancer J. Nutr., December 1, 2007; 137(12): 2599 - 2607. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S. Russell, S. O. McGee, M. M. Ip, D. Kuhlmann, and P. A. Masso-Welch Conjugated Linoleic Acid Induces Mast Cell Recruitment during Mouse Mammary Gland Stromal Remodeling J. Nutr., May 1, 2007; 137(5): 1200 - 1207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. H. J. Kim, W. C. Willett, G. A. Colditz, S. E. Hankinson, M. J. Stampfer, D. J. Hunter, B. Rosner, and M. D. Holmes Dietary Fat and Risk of Postmenopausal Breast Cancer in a 20-year Follow-up Am. J. Epidemiol., November 15, 2006; 164(10): 990 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Kuhnt, A. Wagner, J. Kraft, S. Basu, and G. Jahreis Dietary supplementation with 11trans- and 12trans-18:1 and oxidative stress in humans. Am. J. Clinical Nutrition, November 1, 2006; 84(5): 981 - 988. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. H. MacLean, S. J. Newberry, W. A. Mojica, P. Khanna, A. M. Issa, M. J. Suttorp, Y.-W. Lim, S. B. Traina, L. Hilton, R. Garland, et al. Effects of Omega-3 Fatty Acids on Cancer Risk: A Systematic Review JAMA, January 25, 2006; 295(4): 403 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. McCullough, C. Rodriguez, W. R. Diver, H. S. Feigelson, V. L. Stevens, M. J. Thun, and E. E. Calle Dairy, Calcium, and Vitamin D Intake and Postmenopausal Breast Cancer Risk in the Cancer Prevention Study II Nutrition Cohort Cancer Epidemiol. Biomarkers Prev., December 1, 2005; 14(12): 2898 - 2904. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. E. McCann, C. Ip, M. M. Ip, M. K. McGuire, P. Muti, S. B. Edge, M. Trevisan, and J. L. Freudenheim Dietary Intake of Conjugated Linoleic Acids and Risk of Premenopausal and Postmenopausal Breast Cancer, Western New York Exposures and Breast Cancer Study (WEB Study) Cancer Epidemiol. Biomarkers Prev., September 1, 2004; 13(9): 1480 - 1484. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. G Moorman and P. D Terry Consumption of dairy products and the risk of breast cancer: a review of the literature Am. J. Clinical Nutrition, July 1, 2004; 80(1): 5 - 14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A Watkins, Y. Li, H. E Lippman, S. Reinwald, and M. F Seifert A test of Ockham's razor: implications of conjugated linoleic acid in bone biology Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1175S - 1185S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J Field and P. D Schley Evidence for potential mechanisms for the effect of conjugated linoleic acid on tumor metabolism and immune function: lessons from n-3 fatty acids Am. J. Clinical Nutrition, June 1, 2004; 79(6): 1190S - 1198S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. A. Masso-Welch, D. Zangani, C. Ip, M. M. Vaughan, S. F. Shoemaker, S. O. McGee, and M. M. Ip Isomers of Conjugated Linoleic Acid Differ in Their Effects on Angiogenesis and Survival of Mouse Mammary Adipose Vasculature J. Nutr., February 1, 2004; 134(2): 299 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. A. Corl, D. M. Barbano, D. E. Bauman, and C. Ip cis-9, trans-11 CLA Derived Endogenously from trans-11 18:1 Reduces Cancer Risk in Rats J. Nutr., September 1, 2003; 133(9): 2893 - 2900. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
