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American Journal of Clinical Nutrition, Vol. 77, No. 1, 160-166, January 2003
© 2003 American Society for Clinical Nutrition

Original Research Communication

Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase {gamma}-tocopherol in vivo after adjustment for dietary antioxidant intakes1,2,3

Marion Dietrich, Gladys Block, Edward P Norkus, Mark Hudes, Maret G Traber, Carroll E Cross and Lester Packer

1 From the School of Public Health (MD and GB) and the Department of Nutritional Sciences (MH), University of California, Berkeley; the Department of Biomedical Research, Our Lady of Mercy Medical Center, Bronx, NY (EPN); the University of California, Davis, School of Medicine, Sacramento (MGT and CEC); the Department of Nutrition and Food Management, Linus Pauling Institute, Oregon State University, Corvallis, (MGT); and the Department of Molecular Pharmacology and Toxicology, University of Southern California, Los Angeles (LP).

Background: Free radicals in cigarette smoke may cause oxidative damage to macromolecules, contributing to cardiovascular diseases and cancer. Decreased plasma antioxidant concentrations may indicate cigarette smoke–related oxidative stress.

Objective: We compared the effects on plasma antioxidant concentrations in cotinine-confirmed active and passive smokers with those in nonsmokers, independent of differences in dietary intakes and other covariates.

Design: Plasma samples from 83 smokers, 40 passive smokers, and 36 nonsmokers were analyzed for total ascorbic acid, {alpha}- and {gamma}-tocopherols, 5 carotenoids, retinol, and cotinine. Groups were compared by using analysis of variance with adjustment for sex, age, race, body mass index, alcohol intake, triacylglycerol concentration, fruit and vegetable intakes, and dietary antioxidants.

Results: After adjustment for dietary antioxidant intakes and other covariates, smokers and passive smokers had significantly lower plasma ß-carotene concentrations than did nonsmokers (0.15, 0.17, and 0.24 µmol/L, respectively) and significantly higher {gamma}-tocopherol concentrations (7.8, 7.8, and 6.5 µmol/L, respectively). Smokers had significantly lower plasma ascorbic acid and ß-cryptoxanthin concentrations than did nonsmokers and passive smokers (ascorbic acid: 43.6, 54.5, and 54.6 µmol/L, respectively; ß-cryptoxanthin: 0.12, 0.16, and 0.16 µmol/L, respectively) and significantly lower concentrations of lutein and zeaxanthin than did nonsmokers (0.33 compared with 0.41 µmol/L). The P values for all the differences described above were < 0.05. No significant differences in plasma concentrations of {alpha}-tocopherol, {alpha}-carotene, total carotenoids, lycopene, or retinol were observed.

Conclusions: These results indicate that cigarette smokers and nonsmokers exposed to cigarette smoke have a significantly lower plasma antioxidant status than do unexposed nonsmokers, independent of differences in dietary antioxidant intakes. Further research is required to explain why plasma {gamma}-tocopherol concentrations were significantly higher in smokers and passive smokers than in nonsmokers.

Key Words: Hydrophilic antioxidants • lipophilic antioxidants • {gamma}-tocopherol • smokers • passive smokers • environmental tobacco smoke • body mass index • dietary micronutrients




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