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Effect of short-chain fructooligosaccharides on intestinal calcium absorption and calcium status in postmenopausal women: a stable-isotope study^1,2,3

¹ From the Centre de Recherche en Nutrition Humaine d’Auvergne, Unité Maladies Métaboliques et Micronutriments, Centre de Recherche INRA Clermont-Ferrand/Theix, Saint Genès Champanelle, France (MT, JCT, CF-C, YR, and CC); the Laboratoire de Biologie de Stress Oxydant, Faculté de Pharmacie, Domaine de la Merci, La Tronche, France (JA, VD, and AMR); Nutri-Health, Rueil-Malmaison, France (FRJB); the Laboratoire de Nutrition Humaine, Centre de Recherche en Nutrition Humaine d’Auvergne, Clermont-Ferrand, France (CB-D and MB); the Laboratoire de Contrôle des Eaux, Institut Louise Blanquet, Faculté de Médecine et Pharmacie, Clermont-Ferrand, France (DP); Eridania Béghin-Say, Vilvoorde, Belgium (FB); and the Nutrition and Toxicology Research Institute, Maastricht University, Maastricht, Netherlands (FB).

Background: An enhancing effect of short-chain fructooligosaccharides (scFOSs) on intestinal calcium absorption has been shown in animals and in some short-term human studies. However, the long-term effect of scFOSs on calcium absorption in humans is still unknown.

Objective: We investigated the long-term effect of a moderate daily dose (10 g) of scFOSs on intestinal calcium absorption in postmenopausal women.

Design: In a randomized, double-blind crossover protocol, 12 healthy, postmenopausal women received scFOSs or placebo for 5 wk. The treatments were separated by a 3-wk washout period. Subjects orally received ⁴⁴Ca (stable isotope) and a fecal marker. Feces were collected after the isotope intake for 5–7 d to measure unabsorbed isotope. Calcium-status indexes, calciotropic hormones, and bone turnover were also assessed.

Results: Mean (±SD) intestinal calcium absorption with scFOS treatment was not significantly different from that with placebo treatment (35.63 ± 9.40% and 36.55 ± 8.48%, respectively). However, a tendency for calcium absorption to be higher with scFOS treatment than with placebo treatment was observed in women who had been going through menopause for >6 y.

Conclusions: scFOSs do not modify intestinal calcium absorption in postmenopausal women who do not receive hormonal replacement therapy. The results from a subgroup of women who had been going through menopause for >6 y (n = 6) suggest that scFOSs may influence calcium absorption in the late postmenopausal phase. The small number of subjects and the related P value warrant verification and further investigation with women in late menopause only.

Key Words: Short-chain fructooligosaccharides • fermentation • intestinal absorption • calcium • stable isotopes • postmenopausal women • bone turnover • ⁴⁴Ca

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