| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Original Research Communication |
1 From the Center for Human Nutrition and the Department of Internal Medicine, Washington University School of Medicine, St Louis.
Background: Plasma fatty acid availability is a major regulator of VLDL-triacylglycerol production. Basal whole-body lipolysis is higher in women than in men and is higher in persons with abdominal obesity than in lean individuals.
Objective: Our goal was to determine whether sex and abdominal obesity affect VLDL-triacylglycerol kinetics. We hypothesized that basal VLDL-triacylglycerol production would be greater in women than in men and greater in obese than in lean subjects.
Design: VLDL-triacylglycerol kinetics were measured in 20 lean (10 men, 10 women; body mass index, in kg/m2: 23 ± 1) and 20 abdominally obese (10 men, 10 women; body mass index: 35 ± 1) subjects by using a bolus injection of [2H5]glycerol and compartmental modeling analysis.
Results: The rate of VLDL-triacylglycerol secretion was greater in the lean women than in the lean men (5.1 ± 0.7 and 2.6 ± 0.3 µmol · L plasma-1 · min-1, respectively; P < 0.002). Obesity was associated with increased VLDL-triacylglycerol secretion in the men (P < 0.001) but not in the women, which resulted in greater rates of VLDL-triacylglycerol secretion in the obese men than in the obese women (6.8 ± 0.5 and 5.0 ± 0.5 µmol · L plasma-1 · min-1, respectively; P < 0.05). The clearance of VLDL-triacylglycerol from plasma was greater (P < 0.05) in the lean women than in the lean men (42 ± 7 and 27 ± 4 mL plasma/min, respectively) or in the obese men and obese women (28 ± 3 and 20 ± 4 mL plasma/min, respectively). The plasma VLDL-triacylglycerol concentration was directly related to the rate of VLDL-triacylglycerol secretion in the men (R2 = 0.79, P < 0.001) and inversely related to VLDL-triacylglycerol clearance in the women (R2 = 0.84, P<0.001).
Conclusion: Sex and obesity have independent effects on basal VLDL-triacylglycerol kinetics.
Key Words: Stable isotopes • mathematical modeling • fatty acid • lipolysis • VLDL-triacylglycerol • kinetics
This article has been cited by other articles:
|
|
 |
|
  L. P. Sorensen, L. C. Gormsen, and S. Nielsen VLDL-TG kinetics: a dual isotope study for quantifying VLDL-TG pool size, production rates, and fractional oxidation in humans Am J Physiol Endocrinol Metab, December 1, 2009; 297(6): E1324 - E1330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Gormsen, B. Nellemann, L. P. Sorensen, M. D. Jensen, J. S. Christiansen, and S. Nielsen Impact of body composition on very-low-density lipoprotein-triglycerides kinetics Am J Physiol Endocrinol Metab, January 1, 2009; 296(1): E165 - E173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. P. Konhilas and L. A. Leinwand The Effects of Biological Sex and Diet on the Development of Heart Failure Circulation, December 4, 2007; 116(23): 2747 - 2759. [Full Text] [PDF]
|
|
|
|
 |
|
 F. Magkos, B. W. Patterson, B. S. Mohammed, S. Klein, and B. Mittendorfer Women Produce Fewer but Triglyceride-Richer Very Low-Density Lipoproteins than Men J. Clin. Endocrinol. Metab., April 1, 2007; 92(4): 1311 - 1318. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Ramakrishnan Studying apolipoprotein turnover with stable isotope tracers: correct analysis is by modeling enrichments J. Lipid Res., December 1, 2006; 47(12): 2738 - 2753. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Gormsen, M. D. Jensen, O. Schmitz, N. Moller, J. S. Christiansen, and S. Nielsen Energy expenditure, insulin, and VLDL-triglyceride production in humans J. Lipid Res., October 1, 2006; 47(10): 2325 - 2332. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Horton, E. K. Miller, and K. Bourret No effect of menstrual cycle phase on glycerol or palmitate kinetics during 90 min of moderate exercise J Appl Physiol, March 1, 2006; 100(3): 917 - 925. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. C. Gormsen, M. D. Jensen, and S. Nielsen Measuring VLDL-triglyceride turnover in humans using ex vivo-prepared VLDL tracer J. Lipid Res., January 1, 2006; 47(1): 99 - 106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. L. Isley, J. M. Miles, B. W. Patterson, and W. S. Harris The effect of high-dose simvastatin on triglyceride-rich lipoprotein metabolism in patients with type 2 diabetes mellitus J. Lipid Res., January 1, 2006; 47(1): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. E. Hjelte and A. Nilsson Arachidonic Acid and Ischemic Heart Disease J. Nutr., September 1, 2005; 135(9): 2271 - 2273. [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ribalta, C. J.M. Halkes, J. Salazar, L. Masana, and M. C. Cabezas Additive Effects of the PPAR{gamma}, APOE, and FABP-2 Genes in Increasing Daylong Triglycerides of Normolipidemic Women to Concentrations Comparable to Those in Men Clin. Chem., May 1, 2005; 51(5): 864 - 871. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Mittendorfer Sexual Dimorphism in Human Lipid Metabolism J. Nutr., April 1, 2005; 135(4): 681 - 686. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. H Knopp and B. M Retzlaff Saturated fat prevents coronary artery disease? An American paradox Am. J. Clinical Nutrition, November 1, 2004; 80(5): 1102 - 1103. [Full Text] [PDF]
|
|
|
|
|
|
J. S. Cohn, B. W. Patterson, K. D. Uffelman, J. Davignon, and G. Steiner Rate of Production of Plasma and Very-Low-Density Lipoprotein (VLDL) Apolipoprotein C-III Is Strongly Related to the Concentration and Level of Production of VLDL Triglyceride in Male Subjects with Different Body Weights and Levels of Insulin Sensitivity J. Clin. Endocrinol. Metab., August 1, 2004; 89(8): 3949 - 3955. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
