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Original Research Communication |
1 From the Nutrition Food and Health Research Centre, King’s College London (TABS and SEEB), and the Medical Research Council Cardiovascular Group, Wolfson Institute, St Bartholomew’s and the Royal London School of Medicine and Dentistry, Charterhouse Square, London (GJM).
Background: The consumption of a synthetic, randomized, stearic acid–rich triacylglycerol results in decreased postprandial lipemia and activated factor VII (FVII:a) compared with cocoa butter (a nonrandomized, symmetrical, stearic acid–rich triacylglycerol). It was hypothesized that this difference is a consequence of the differences in structure between the 2 triacylglycerols.
Objective: The objective was to test whether the consumption of randomized cocoa butter decreases postprandial lipemia and FVII:a.
Design: A randomized crossover trial with 17 male subjects compared the effects of meals containing 50 g fat provided as a symmetrical (cocoa butter) or an asymmetrical (randomized cocoa butter) triacylglycerol on postprandial changes in lipids, chylomicron composition, and FVII:a.
Results: After randomization, the postprandial area under the curve for plasma triacylglycerol decreased by 41% (P < 0.01). At 3 h the plasma concentrations of triacylglycerol, palmitic acid, stearic acid, and oleic acid were 26%, 18%, 34%, and 19% lower, respectively. The proportion of oleic acid in the sn-2 position of the chylomicron triacylglycerol was reduced from 67.4 mol% to 35.9 mol% and resulted in an increase in the proportion of stearic acid in the sn-2 position from 9.2 mol% to 25.4 mol%. FVII:a did not increase 6 h after consumption of the randomized cocoa butter (
: 1.2; 95% CI: -2.7, 4.6 U/L) but increased significantly (: 7.7; 95% CI: 2.5,12.9 U/L) 6 h after consumption of the unrandomized cocoa butter.
Conclusions: Symmetrical stearic acid–rich triacylglycerol with oleic acid in the sn-2 position appears to be absorbed more rapidly than is asymmetrical triacylglycerols with long-chain saturated fatty acids in the sn-2 position, which leads to activation of FVII.
Key Words: Factor VII • stearic acid • postprandial lipemia • saturated fatty acids • triacylglycerols • digestion
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