HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kelleher, S. L Articles by Lönnerdal, B. Search for Related Content PubMed PubMed Citation Articles by Kelleher, S. L Articles by Lönnerdal, B. Agricola Articles by Kelleher, S. L Articles by Lönnerdal, B.

Glycomacropeptide and -lactalbumin supplementation of infant formula affects growth and nutritional status in infant rhesus monkeys^1,2,3

¹ From the Department of Nutrition and California National Primate Research Center, University of California, Davis (SLK and BL), and Arla Foods AMBA (DC) and Arla Foods Ingredients, Viby, Denmark (KN).

Background: Advances in dairy technology make it possible to enrich infant formula with specific bovine milk components that may enhance nutrient status. Glycomacropeptide, a carbohydrate-rich casein peptide, may increase absorption of calcium, iron, or zinc. -Lactalbumin, a major breast-milk protein, may contribute to a balanced amino acid pattern and increase calcium and zinc absorption.

Objective: We determined the effects of glycomacropeptide- and -lactalbumin–supplemented infant formula on growth; trace mineral status; iron, zinc, and calcium absorption; and plasma amino acid, blood urea nitrogen, and plasma insulin concentrations.

Design: Infant rhesus monkeys (n = 5 infants per group) were breastfed or fed control or -lactalbumin– or glycomacropeptide-supplemented formula from birth to 4 mo of age. Hematologic measures and growth were assessed monthly. Mineral absorption was measured with radioisotopes and whole body counting.

Results: Infants fed glycomacropeptide had higher food intake than did other formula-fed infants. Infants fed glycomacropeptide or control formula had higher hematocrit values than did infants that were breastfed or fed -lactalbumin. Infants fed glycomacropeptide or control formula had higher plasma zinc and zinc absorption than did breastfed infants. Where differences were observed, breastfed infants and infants fed -lactalbumin had similar plasma essential amino acid and insulin profiles, which were different from those of infants fed glycomacropeptide or control formula.

Conclusions: Glycomacropeptide- or -lactalbumin–supplemented formula has no adverse effects on nutritional status in infant monkeys. Glycomacropeptide supplementation increases zinc absorption, which may permit the reduction of formula zinc concentrations, and -lactalbumin supplementation promotes a plasma amino acid pattern similar to that of breastfed infant monkeys.

Key Words: Glycomacropeptide • -lactalbumin • formula • infants • monkeys • amino acids • trace minerals

This article has been cited by other articles:

				O. Sandstrom, B. Lonnerdal, G. Graverholt, and O. Hernell Effects of {alpha}-lactalbumin-enriched formula containing different concentrations of glycomacropeptide on infant nutrition Am. J. Clinical Nutrition, April 1, 2008; 87(4): 921 - 928. [Abstract] [Full Text] [PDF]

				B. L. Luhovyy, T. Akhavan, and G. H. Anderson Whey Proteins in the Regulation of Food Intake and Satiety J. Am. Coll. Nutr., December 1, 2007; 26(6): 704S - 712S. [Abstract] [Full Text] [PDF]

				G. W. Krissansen Emerging Health Properties of Whey Proteins and Their Clinical Implications J. Am. Coll. Nutr., December 1, 2007; 26(6): 713S - 723S. [Abstract] [Full Text] [PDF]