| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Gastroenterology and Nutrition, The Children’s Hospital of Philadelphia (NS, BSZ, and VAS), the Center for Clinical Epidemiology and Biostatistics (NS and SKK), and the WM Krogman Center for Research in Child Growth and Development (SHK), University of Pennsylvania School of Medicine, Philadelphia.
Background: Obesity is increasing in the United States. Evidence-based prevention is a public health priority and should target well-defined risk factors and critical periods.
Objective: We tested the hypothesis that rapid weight gain during early infancy is associated with obesity in African American young adults, a group at increased risk of obesity.
Design: A cohort of 300 African Americans born at full term was followed from birth to 20 y of age. A pattern of rapid weight gain was defined as an increase in weight-for-age ≥ 1 SD between birth and 4 mo.
Results: About 29% of subjects had a pattern of rapid weight gain during infancy; 8% were obese [body mass index (in kg/m2) ≥ 30] at age 20 y. One-third of the obesity at age 20 y could be attributed to rapid weight gain in the first 4 mo of life. After adjustment for confounding factors, subjects with rapid weight gain during early infancy were more likely to become obese at age 20 y (odds ratio = 5.22; 95% CI: 1.55, 17.6; P = 0.008). The results were confirmed by using a combination of body mass index and skinfold thickness (odds ratio = 6.72; 95% CI: 1.93, 23.4; P = 0.003).
Conclusions: The results of the present study provide evidence that a pattern of rapid weight gain during early infancy is associated with obesity not only in childhood but also in young adulthood. We propose that early infancy constitutes a critical period for the development of obesity. Mechanisms of action and prevention strategies require further investigation.
Key Words: Birth order • birth weight • African Americans • children • cohort studies • growth • infants • obesity • skinfold thickness • weight gain
Related articles in AJCN:
This article has been cited by other articles:
|
|
 |
|
  M A Hyatt, D H Keisler, H Budge, and M E Symonds Maternal parity and its effect on adipose tissue deposition and endocrine sensitivity in the postnatal sheep J. Endocrinol., February 1, 2010; 204(2): 173 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ceelen, M. M. van Weissenbruch, J. Prein, J. J. Smit, J. P.W. Vermeiden, M. Spreeuwenberg, F. E. van Leeuwen, and H. A. Delemarre-van de Waal Growth during infancy and early childhood in relation to blood pressure and body fat measures at age 8-18 years of IVF children and spontaneously conceived controls born to subfertile parents Hum. Reprod., November 1, 2009; 24(11): 2788 - 2795. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Koletzko, R. von Kries, R. C. Monasterolo, J. E. Subias, S. Scaglioni, M. Giovannini, J. Beyer, H. Demmelmair, B. Anton, D. Gruszfeld, et al. Can infant feeding choices modulate later obesity risk? Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1502S - 1508S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. M. Taveras, S. L. Rifas-Shiman, M. B. Belfort, K. P. Kleinman, E. Oken, and M. W. Gillman Weight Status in the First 6 Months of Life and Obesity at 3 Years of Age Pediatrics, April 1, 2009; 123(4): 1177 - 1183. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Kavikondala, C. Schooling, C. Jiang, W. Zhang, K. Cheng, T. Lam, and G. Leung Pathways to obesity in a developing population: The Guangzhou Biobank Cohort Study Int. J. Epidemiol., February 1, 2009; 38(1): 72 - 82. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chomtho, J. C. Wells, J. E Williams, P. S. Davies, A. Lucas, and M. S Fewtrell Infant growth and later body composition: evidence from the 4-component model, Am. J. Clinical Nutrition, June 1, 2008; 87(6): 1776 - 1784. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P J Surkan, I Kawachi, and K E Peterson Childhood overweight and maternal depressive symptoms J Epidemiol Community Health, May 1, 2008; 62(5): e11 - e11. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Corl, S. A. Mathews Oliver, X. Lin, W. T. Oliver, Y. Ma, R. J. Harrell, and J. Odle Conjugated Linoleic Acid Reduces Body Fat Accretion and Lipogenic Gene Expression in Neonatal Pigs Fed Low- or High-Fat Formulas J. Nutr., March 1, 2008; 138(3): 449 - 454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. F. Krebs, J. H. Himes, D. Jacobson, T. A. Nicklas, P. Guilday, and D. Styne Assessment of Child and Adolescent Overweight and Obesity Pediatrics, December 1, 2007; 120(Supplement_4): S193 - S228. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. McCarthy, R. Hughes, K. Tilling, D. Davies, G. Davey Smith, and Y. Ben-Shlomo Birth weight; postnatal, infant, and childhood growth; and obesity in young adulthood: evidence from the Barry Caerphilly Growth Study Am. J. Clinical Nutrition, October 1, 2007; 86(4): 907 - 913. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C Corvalan, C. Gregory, M Ramirez-Zea, R Martorell, and A. Stein Size at birth, infant, early and later childhood growth and adult body composition: a prospective study in a stunted population Int. J. Epidemiol., June 1, 2007; 36(3): 550 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. D. Taylor and L. Poston Developmental programming of obesity in mammals Exp Physiol, March 1, 2007; 92(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. S. Muhlhausler, J. A. Duffield, and I. C. McMillen Increased Maternal Nutrition Stimulates Peroxisome Proliferator Activated Receptor-{gamma}, Adiponectin, and Leptin Messenger Ribonucleic Acid Expression in Adipose Tissue before Birth Endocrinology, February 1, 2007; 148(2): 878 - 885. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. J Ellis, M. Yao, R. J Shypailo, A. Urlando, W. W Wong, and W. C Heird Body-composition assessment in infancy: air-displacement plethysmography compared with a reference 4-compartment model Am. J. Clinical Nutrition, January 1, 2007; 85(1): 90 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Karaolis-Danckert, A. E Buyken, K. Bolzenius, C. Perim de Faria, M. J Lentze, and A. Kroke Rapid growth among term children whose birth weight was appropriate for gestational age has a longer lasting effect on body fat percentage than on body mass index Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1449 - 1455. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. J. Mayer-Davis, S. L. Rifas-Shiman, L. Zhou, F. B. Hu, G. A. Colditz, and M. W. Gillman Breast-Feeding and Risk for Childhood Obesity: Does maternal diabetes or obesity status matter? Diabetes Care, October 1, 2006; 29(10): 2231 - 2237. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. K. Ong, P. M. Emmett, S. Noble, A. Ness, D. B. Dunger, and and the ALSPAC Study Team Dietary Energy Intake at the Age of 4 Months Predicts Postnatal Weight Gain and Childhood Body Mass Index Pediatrics, March 1, 2006; 117(3): e503 - e508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Ekelund, K. Ong, Y. Linne, M. Neovius, S. Brage, D. B Dunger, N. J Wareham, and S. Rossner Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES) Am. J. Clinical Nutrition, February 1, 2006; 83(2): 324 - 330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Kinra, J H Baumer, and G Davey Smith Early growth and childhood obesity: a historical cohort study Arch. Dis. Child., November 1, 2005; 90(11): 1122 - 1127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Baird, D. Fisher, P. Lucas, J. Kleijnen, H. Roberts, and C. Law Being big or growing fast: systematic review of size and growth in infancy and later obesity BMJ, October 22, 2005; 331(7522): 929. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Makrides, R. A Gibson, T. Udell, K. Ried, and the International LCPUFA Investigators Supplementation of infant formula with long-chain polyunsaturated fatty acids does not influence the growth of term infants Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1094 - 1101. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Stettler, V. A. Stallings, A. B. Troxel, J. Zhao, R. Schinnar, S. E. Nelson, E. E. Ziegler, and B. L. Strom Weight Gain in the First Week of Life and Overweight in Adulthood: A Cohort Study of European American Subjects Fed Infant Formula Circulation, April 19, 2005; 111(15): 1897 - 1903. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Smith Jr, L. T. Clark, R. S. Cooper, S. R. Daniels, S. K. Kumanyika, E. Ofili, M. A. Quinones, E. J. Sanchez, E. Saunders, and S. D. Tiukinhoy Discovering the Full Spectrum of Cardiovascular Disease: Minority Health Summit 2003: Report of the Obesity, Metabolic Syndrome, and Hypertension Writing Group Circulation, March 15, 2005; 111(10): e134 - e139. [Full Text] [PDF]
|
|
|
|
|
|
A. M Euser, M. J. Finken, M. G Keijzer-Veen, E. T. Hille, J. M Wit, F. W Dekker, and on behalf of the Dutch POPS-19 Collaborative Study Associations between prenatal and infancy weight gain and BMI, fat mass, and fat distribution in young adulthood: a prospective cohort study in males and females born very preterm Am. J. Clinical Nutrition, February 1, 2005; 81(2): 480 - 487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. Toschke, V. Grote, B. Koletzko, and R. von Kries Identifying Children at High Risk for Overweight at School Entry by Weight Gain During the First 2 Years Arch Pediatr Adolesc Med, May 1, 2004; 158(5): 449 - 452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. A Yanovski Rapid weight gain during infancy as a predictor of adult obesity Am. J. Clinical Nutrition, June 1, 2003; 77(6): 1350 - 1351. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
