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Efficiency of calcium absorption is not compromised in clinically stable prepubertal and pubertal girls with cystic fibrosis^1,2,3,4

¹ From the Center of Human Nutrition, The Johns Hopkins University Bloomberg School of Public Health, Baltimore (KJS and KOO); the Division of Pediatric Endocrinology, The Johns Hopkins University School of Medicine, Baltimore (ELG-L); the US Department of Agriculture, Agricultural Research Service, Beltsville Human Nutrition Research Center, Beltsville, MD (DJB); and the Department of Pediatrics, The Johns Hopkins Hospital, Baltimore (AL and BJR).

Background: Reduced bone mass is common in both children and adults with cystic fibrosis (CF) and may be a consequence of inadequate calcium absorption. The effect of CF on intestinal calcium absorption and retention has not been described in children.

Objective: Calcium absorption and urinary losses were characterized in clinically stable girls with CF consuming self-selected diets and following usual pancreatic enzyme regimens.

Design: The percentage of calcium absorption was assessed in 23 girls (aged 7–18 y) with CF by using oral (⁴⁴Ca) and intravenous (⁴²Ca) stable isotopes. Girls were grouped according to Tanner stage of breast development. True calcium absorption (V_a) was determined as the product of percentage calcium absorption and average 4-d daily calcium intake. Calcium balance was estimated by subtracting urinary calcium and estimated endogenous fecal losses from the measure of V_a. Analysis of variance was used to compare outcomes among pubertal groups, and regression analysis was used to describe the relations of percentage and total calcium absorption to calcium intake and of urinary calcium to sodium excretion.

Results: Percentage calcium absorption was inversely related to calcium intake. Percentage absorption and V_a were similar to values observed in healthy girls in other studies. Total calcium absorption and estimated calcium balance were significantly greater among girls in early puberty (Tanner stages 2–3) than in prepubertal or late-pubertal girls (P < 0.05). Urinary calcium was positively related to urinary sodium excretion (P = 0.02).

Conclusion: The efficiency of calcium absorption was not compromised in clinically stable girls with CF.

Key Words: Cystic fibrosis • bone • calcium • stable isotopes • puberty • girls

This article has been cited by other articles:

				K. J. Schulze, K. O. O'Brien, E. L. Germain-Lee, S. L. Booth, A. Leonard, and B. J. Rosenstein Calcium Kinetics Are Altered in Clinically Stable Girls with Cystic Fibrosis J. Clin. Endocrinol. Metab., July 1, 2004; 89(7): 3385 - 3391. [Abstract] [Full Text] [PDF]