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ORIGINAL RESEARCH COMMUNICATION |
1 From the Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston (PFJ, SMM, GR, and AT); the Tufts University School of Nutrition Science and Policy, Boston (PFJ, SMM, and AT); The Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston (SEH and WCW); the Departments of Nutrition (WCW) and Epidemiology (SEH and WCW), Harvard School of Public Health, Boston; the Center for Ophthalmic Research, Brigham and Women’s Hospital, Boston (WT, JKW, and LTC); and the Harvard Medical School, Boston (LTC).
Background: The association between weight status and the risk of lens opacities has received little attention.
Objective: We examined the cross-sectional relations of body mass index (BMI; in kg/m2), waist circumference, and diabetes with the presence of age-related lens opacities.
Design: Eye examinations were conducted in 466 Boston-area women aged 53–73 y who were without previously diagnosed cataracts and were part of the Nurses’ Health Study cohort. Weight, height, waist, and hip measurements were obtained by self-report. Lens status was evaluated by using the Lens Opacification Classification System III (LOCS III). BMI and waist circumference were used as measures of overweight and abdominal adiposity, respectively. Nuclear, cortical, and posterior subcapsular (PSC) opacities were defined as LOCS III scores 
2.5, 1.0, and 0.5, respectively. Diabetes was defined as a history of type 2 diabetes or as a fasting plasma glucose concentration 7.0 mmol/L.
Results: Women with diabetes were significantly more likely to have PSC opacities [odds ratio (OR): 4.1; 95% CI: 1.8, 9.4] than were women with fasting plasma glucose concentrations < 6.1 mmol/L. Women with a BMI 30 had a higher prevalence of PSC opacities than did women with a BMI < 25 (OR: 2.5; 1.2, 5.2), and women with a waist circumference 89 cm had a higher prevalence of PSC opacities than did those with a waist circumference < 80 cm (OR: 2.3; 1.0, 5.2). Diabetes and measures of adiposity were unrelated to the prevalence of cortical and nuclear opacities.
Conclusions: Diabetes is a strong risk factor for PSC opacities, and overweight and abdominal adiposity may be risk factors for PSC opacities.
Key Words: Aging • adiposity • blood glucose • body weight • cataract • diabetes mellitus • epidemiology • eye • lens • survey • waist-to-hip ratio
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A. Taylor Reply to J Gomez-Ambrosi et al Am. J. Clinical Nutrition, May 1, 2004; 79(5): 889 - 889. [Full Text] [PDF]
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