| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Supplements |
1 From the School of Allied Health, University of Connecticut, Storrs (JEK); the Johns Hopkins Bloomberg School of Public Health, Center for Human Nutrition, Baltimore (KOO); and the Yale University School of Internal Medicine, New Haven, CT (KLI).
High dietary protein intakes are known to increase urinary calcium excretion and, if maintained, will result in sustained hypercalciuria. To date, the majority of calcium balance studies in humans have not detected an effect of dietary protein on intestinal calcium absorption or serum parathyroid hormone. Therefore, it is commonly concluded that the source of the excess urinary calcium is increased bone resorption. Recent studies from our laboratory indicate that alterations in dietary protein can, in fact, profoundly affect intestinal calcium absorption. In short-term dietary trials in healthy adults, we fixed calcium intake at 20 mmol/d while dietary protein was increased from 0.7 to 2.1 g/kg. Increasing dietary protein induced hypercalciuria in 20 women [from 3.4 ± 0.3 (
± SE) during the low-protein to 5.4 ± 0.4 mmol/d during the high-protein diet]. The increased dietary protein was accompanied by a significant increase in intestinal calcium absorption from 18.4 ± 1.3% to 26.3 ± 1.5% (as determined by dual stable isotopic methodology). Dietary protein intakes at and below 0.8 g/kg were associated with a probable reduction in intestinal calcium absorption sufficient to cause secondary hyperparathyroidism. The long-term consequences of these low-protein diet–induced changes in mineral metabolism are not known, but the diet could be detrimental to skeletal health. Of concern are several recent epidemiologic studies that demonstrate reduced bone density and increased rates of bone loss in individuals habitually consuming low-protein diets. Studies are needed to determine whether low protein intakes directly affect rates of bone resorption, bone formation, or both.
Key Words: Dietary protein • urinary calcium • parathyroid hormone • vitamin D • hypercalciuria • bone • soy
This article has been cited by other articles:
|
|
 |
|
  J. E Kerstetter Dietary protein and bone: a new approach to an old question Am. J. Clinical Nutrition, December 1, 2009; 90(6): 1451 - 1452. [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Bonjour and T. Chevalley The Dietary Protein-Acidosis Hypothesis in the Pathophysiology of Osteoporosis IBMS BoneKEy, July 1, 2009; 6(7): 254 - 258. [Full Text] [PDF]
|
|
|
|
 |
|
 C. Lorincz, S. L. Manske, and R. Zernicke Bone Health: Part 1, Nutrition Sports Health: A Multidisciplinary Approach, May 1, 2009; 1(3): 253 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P Heaney and D. K Layman Amount and type of protein influences bone health Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1567S - 1570S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-P. Bonjour Dietary Protein: An Essential Nutrient For Bone Health J. Am. Coll. Nutr., December 1, 2005; 24(suppl_6): 526S - 536S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Alexy, T. Remer, F. Manz, C. M Neu, and E. Schoenau Long-term protein intake and dietary potential renal acid load are associated with bone modeling and remodeling at the proximal radius in healthy children Am. J. Clinical Nutrition, November 1, 2005; 82(5): 1107 - 1114. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Frick, K. LaPlante, and D. A. Bushinsky RANK ligand and TNF-{alpha} mediate acid-induced bone calcium efflux in vitro Am J Physiol Renal Physiol, November 1, 2005; 289(5): F1005 - F1011. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. R. Zwart, J. E. Davis-Street, D. Paddon-Jones, A. A. Ferrando, R. R. Wolfe, and S. M. Smith Amino acid supplementation alters bone metabolism during simulated weightlessness J Appl Physiol, July 1, 2005; 99(1): 134 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Devine, I. M Dick, A. F. Islam, S. S Dhaliwal, and R. L Prince Protein consumption is an important predictor of lower limb bone mass in elderly women Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1423 - 1428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Ballard, J. A Clapper, B. L Specker, T. L Binkley, and M. D Vukovich Effect of protein supplementation during a 6-mo strength and conditioning program on insulin-like growth factor I and markers of bone turnover in young adults Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1442 - 1448. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Remer Estimates of renal net acid excretion and bone health Am. J. Clinical Nutrition, September 1, 2004; 80(3): 786 - 786. [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Heinig and K. Doberne Weighing the Risks: the Use of Low-Carbohydrate Diets During Lactation J Hum Lact, August 1, 2004; 20(3): 283 - 285. [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
