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Vitamin C and cancer chemoprevention: reappraisal^1,2,3

¹ From the Department of Food Science and Technology, School of Agricultural Biotechnology (KWL and HJL) and the College of Pharmacy (Y-JS), Seoul National University, Seoul, South Korea, and the Department of Food Science and Technology, Cornell University, Geneva, NY (KWL and CYL).

Several studies have reported that even a moderate daily dose of supplementary vitamin C (200 mg) induces the formation of genotoxins from lipid hydroperoxides, thereby resulting in DNA damage and initiation of carcinogenesis. However, other reports questioned the experimental designs used and suggested that the chemopreventive effects of vitamin C may be linked to the inhibition of tumor promotion as well as to the blocking of tumor initiation. In this article, we discuss issues of contention and some controversies related to the potential chemopreventive effects of vitamin C in carcinogenesis.

Key Words: Vitamin C • DNA damage • cancer prevention • tumor promotion

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