| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Geriatrics and Metabolic Diseases, Second University of Naples.
Background: A single high-fat meal induces endothelial activation, which is associated with increased serum concentrations of inflammatory cytokines.
Objective: We compared the effect of 3 different meals on circulating concentrations of interleukin 8 (IL-8), interleukin 18 (IL-18), and adiponectin in healthy subjects and in patients with type 2 diabetes mellitus.
Design: Thirty patients with newly diagnosed type 2 diabetes and 30 matched, nondiabetic subjects received the following 3 isoenergetic (780 kcal) meals separated by 1-wk intervals: a high-fat meal; a high-carbohydrate, low-fiber (4.5 g) meal; and a high-carbohydrate, high-fiber meal in which refined-wheat flour was replaced with whole-wheat flour (16.8 g). We analyzed serum glucose and lipid variables and serum IL-8, IL-18, and adiponectin concentrations at baseline and at 2 and 4 h after ingestion of the meals.
Results: Compared with nondiabetic subjects, diabetic patients had higher fasting IL-8 (P < 0.05) and IL-18 (P < 0.01) concentrations and lower adiponectin concentrations (P < 0.01) at baseline. In both nondiabetic and diabetic subjects, IL-18 concentrations increased and adiponectin concentrations decreased (P < 0.05) from baseline concentrations after consumption of the high-fat meal. After consumption of the high-carbohydrate, high-fiber meal, serum IL-18 concentrations decreased from baseline concentrations (P < 0.05) in both nondiabetic and diabetic subjects; adiponectin concentrations decreased after the high-carbohydrate, low-fiber meal in diabetic patients. IL-8 concentrations did not change significantly after consumption of any of the 3 meals.
Conclusions: This study provides evidence that circulating IL-18 and adiponectin concentrations are modulated by familiar foodstuffs in humans. Meal modulation of cytokines involved in atherogenesis may represent a safe strategy for ameliorating atherogenetic inflammatory activity in diabetic patients.
Key Words: Type 2 diabetes mellitus • interleukin 8 • interleukin 18 • adiponectin • high-fat meal • high-carbohydrate meal • dietary fiber
This article has been cited by other articles:
|
|
 |
|
  J. P. Crandall, H. Shamoon, H. W. Cohen, M. Reid, S. Gajavelli, G. Trandafirescu, V. Tabatabaie, and N. Barzilai Post-Challenge Hyperglycemia in Older Adults Is Associated with Increased Cardiovascular Risk Profile J. Clin. Endocrinol. Metab., May 1, 2009; 94(5): 1595 - 1601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Maurer, Q. Chen, C. McPherson, and R. A. Reimer Changes in satiety hormones and expression of genes involved in glucose and lipid metabolism in rats weaned onto diets high in fibre or protein reflect susceptibility to increased fat mass in adulthood J. Physiol., February 1, 2009; 587(3): 679 - 691. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Kallio, M. Kolehmainen, D. E Laaksonen, L. Pulkkinen, M. Atalay, H. Mykkanen, M. Uusitupa, K. Poutanen, and L. Niskanen Inflammation markers are modulated by responses to diets differing in postprandial insulin responses in individuals with the metabolic syndrome Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1497 - 1503. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Chandrasekar, D. N. Patel, S. Mummidi, J.-w. Kim, R. A. Clark, and A. J. Valente Interleukin-18 Suppresses Adiponectin Expression in 3T3-L1 Adipocytes via a Novel Signal Transduction Pathway Involving ERK1/2-dependent NFATc4 Phosphorylation J. Biol. Chem., February 15, 2008; 283(7): 4200 - 4209. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shimabukuro, I. Chinen, N. Higa, N. Takasu, K. Yamakawa, and S. Ueda Effects of dietary composition on postprandial endothelial function and adiponectin concentrations in healthy humans: a crossover controlled study Am. J. Clinical Nutrition, October 1, 2007; 86(4): 923 - 928. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Stirban, M. Negrean, B. Stratmann, C. Gotting, J. Salomon, K. Kleesiek, and D. Tschoepe Adiponectin Decreases Postprandially Following a Heat-Processed Meal in Individuals With Type 2 Diabetes: An effect prevented by benfotiamine and cooking method Diabetes Care, October 1, 2007; 30(10): 2514 - 2516. [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Zorrilla, M. Sanchez-Alavez, S. Sugama, M. Brennan, R. Fernandez, T. Bartfai, and B. Conti Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency PNAS, June 26, 2007; 104(26): 11097 - 11102. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Zhang, S. Liu, C. G. Solomon, and F. B. Hu Dietary Fiber Intake, Dietary Glycemic Load, and the Risk for Gestational Diabetes Mellitus Diabetes Care, October 1, 2006; 29(10): 2223 - 2230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Giugliano, A. Ceriello, and K. Esposito The Effects of Diet on Inflammation: Emphasis on the Metabolic Syndrome J. Am. Coll. Cardiol., August 15, 2006; 48(4): 677 - 685. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Esposito and D. Giugliano Whole-grain intake cools down inflammation Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1440 - 1441. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Basu, S. Devaraj, and I. Jialal Dietary Factors That Promote or Retard Inflammation Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 995 - 1001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Jiang, D. R. Jacobs Jr., E. Mayer-Davis, M. Szklo, D. Herrington, N. S. Jenny, R. Kronmal, and R. G. Barr Nut and Seed Consumption and Inflammatory Markers in the Multi-Ethnic Study of Atherosclerosis Am. J. Epidemiol., February 1, 2006; 163(3): 222 - 231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Esposito and D. Giugliano Diet and inflammation: a link to metabolic and cardiovascular diseases Eur. Heart J., January 1, 2006; 27(1): 15 - 20. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Esposito, M. Ciotola, and D. Giugliano Inflammation Warms Up the Metabolic Syndrome Arterioscler. Thromb. Vasc. Biol., November 1, 2005; 25(11): e143 - e143. [Full Text] [PDF]
|
|
|
|
 |
|
 B. Thorand, H. Kolb, J. Baumert, W. Koenig, L. Chambless, C. Meisinger, T. Illig, S. Martin, and C. Herder Elevated Levels of Interleukin-18 Predict the Development of Type 2 Diabetes: Results From the MONICA/KORA Augsburg Study, 1984-2002 Diabetes, October 1, 2005; 54(10): 2932 - 2938. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Galisteo, M. Sanchez, R. Vera, M. Gonzalez, A. Anguera, J. Duarte, and A. Zarzuelo A Diet Supplemented with Husks of Plantago ovata Reduces the Development of Endothelial Dysfunction, Hypertension, and Obesity by Affecting Adiponectin and TNF-{alpha} in Obese Zucker Rats J. Nutr., October 1, 2005; 135(10): 2399 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qi, E. Rimm, S. Liu, N. Rifai, and F. B. Hu Dietary Glycemic Index, Glycemic Load, Cereal Fiber, and Plasma Adiponectin Concentration in Diabetic Men Diabetes Care, May 1, 2005; 28(5): 1022 - 1028. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Esposito, R. Marfella, M. Ciotola, C. Di Palo, F. Giugliano, G. Giugliano, M. D'Armiento, F. D'Andrea, and D. Giugliano Effect of a Mediterranean-Style Diet on Endothelial Dysfunction and Markers of Vascular Inflammation in the Metabolic Syndrome: A Randomized Trial JAMA, September 22, 2004; 292(12): 1440 - 1446. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
