| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATIONS |
1 From the Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston (HDS, JEB, and JMG); the Department of Epidemiology, Harvard School of Public Health, Boston (HDS and JEB); the Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston (HDS and JMG); the Department of Ambulatory Care and Prevention, Harvard Medical School, Boston (JEB); and the Department of Medical Research, Our Lady of Mercy Medical Center, and Community and Preventive Medicine, New York Medical College, Bronx, NY (EPN).
Background: Growing evidence suggests that lycopene has significant in vitro antioxidant potential. Lycopene has rarely been tested in prospective studies for its role in cardiovascular disease (CVD) prevention.
Objective: We examined the association between plasma lycopene and the risk of CVD in middle-aged and elderly women.
Design: A prospective, nested, case-control study was conducted in 39 876 women initially free of CVD and cancer in the Women's Health Study. Baseline blood samples were collected from 28 345 (71%) of the women. During a mean of 4.8 y of follow-up, we identified 483 CVD cases and 483 control subjects matched by age, smoking status, and follow-up time. Plasma lycopene, other carotenoids, retinol, and total cholesterol were measured.
Results: In analyses matched for age and smoking, with adjustment for plasma cholesterol, the relative risks (RRs) and 95% CIs of CVD in increasing quartiles of plasma lycopene were 1.00 (referent), 0.78 (95% CI: 0.55, 1.11), 0.56 (0.39, 0.82), and 0.62 (0.43, 0.90). In multivariate models, the RRs were 1.00 (referent), 0.94 (0.60, 1.49), 0.62 (0.39, 1.00), and 0.67 (0.41, 1.11); those in the upper compared with the lower half of plasma lycopene had an RR of 0.66 (0.47, 0.95). For CVD, exclusive of angina, women in the upper 3 quartiles had a significant multivariate 50% risk reduction compared with those in the lowest quartile. The stepwise addition of individual plasma carotenoids did not affect the RRs.
Conclusions: Higher plasma lycopene concentrations are associated with a lower risk of CVD in women. These findings require confirmation in other cohorts, and the determinants of plasma lycopene concentrations need to be better understood.
Key Words: Lycopene • cardiovascular disease • women • prospective studies • nutrition
This article has been cited by other articles:
|
|
 |
|
  G. Riccioni, T. Bucciarelli, B. Mancini, F. Corradi, C. Di Ilio, P. A. Mattei, and N. D'Orazio Antioxidant Vitamin Supplementation in Cardiovascular Diseases Ann. Clin. Lab. Sci., January 1, 2007; 37(1): 89 - 95. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Wang, S. Liu, A. D. Pradhan, J. E. Manson, J. E. Buring, J. M. Gaziano, and H. D. Sesso Plasma Lycopene, Other Carotenoids, and the Risk of Type 2 Diabetes in Women Am. J. Epidemiol., September 15, 2006; 164(6): 576 - 585. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Voutilainen, T. Nurmi, J. Mursu, and T. H Rissanen Carotenoids and cardiovascular health Am. J. Clinical Nutrition, June 1, 2006; 83(6): 1265 - 1271. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Gajic, S. Zaripheh, F. Sun, and J. W. Erdman Jr. Apo-8'-Lycopenal and Apo-12'-Lycopenal Are Metabolic Products of Lycopene in Rat Liver J. Nutr., June 1, 2006; 136(6): 1552 - 1557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. D Sesso, J. E Buring, E. P Norkus, and J M. Gaziano Plasma lycopene, other carotenoids, and retinol and the risk of cardiovascular disease in men Am. J. Clinical Nutrition, May 1, 2005; 81(5): 990 - 997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. D. Sesso, J. E. Buring, S. M. Zhang, E. P. Norkus, and J. M. Gaziano Dietary and Plasma Lycopene and the Risk of Breast Cancer Cancer Epidemiol. Biomarkers Prev., May 1, 2005; 14(5): 1074 - 1081. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Canene-Adams, J. K. Campbell, S. Zaripheh, E. H. Jeffery, and J. W. Erdman Jr The Tomato As a Functional Food J. Nutr., May 1, 2005; 135(5): 1226 - 1230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Ribaya-Mercado and J. B. Blumberg Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention J. Am. Coll. Nutr., December 1, 2004; 23(suppl_6): 567S - 587S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Stocker and J. F. Keaney Jr. Role of Oxidative Modifications in Atherosclerosis Physiol Rev, October 1, 2004; 84(4): 1381 - 1478. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
