| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the International Centre for Diarrhoeal Diseases Research, Bangladesh (ICDDR,B): Centre for Health and Population Research, Dhaka, Bang-ladesh (RR, SKR, MJR, TA, SSA, and JC), and the Center for Infectious Medicine, Karolinska Institutet, Huddinge University Hospital, Huddinge, Sweden (JA)
Background: Several studies showed benefits of long-term zinc supplementation on the incidence, severity, and duration of diarrhea and on the incidence of respiratory infections. Prolonged zinc supplementation also improves cell-mediated immunity in severely malnourished children.
Objective: We studied the effect of short-term zinc supplementation on intrinsic and specific immune and inflammatory responses in moderately malnourished children with acute shigellosis.
Design: A randomized, double-blind, placebo-controlled trial was conducted in Shigella-infected children aged 12-59 mo. Elemental zinc (20 mg) and a multivitamin containing vitamins A and D, thiamine, riboflavin, nicotinamide, and calcium at twice the recommended dietary allowance were given daily for 2 wk to the zinc group (n = 28), whereas the multivitamin alone was given to the control group (n = 28). Standard antibiotic therapy was given to all patients.
Results: Serum zinc concentrations increased in both groups during convalescence; however, zinc supplementation showed a significant effect. The lymphocyte proliferation response in the zinc group increased relative to that in the control group (P = 0.002), but no significant effects were seen on concentrations of cytokines (interleukin 2 and interferon 
) released from mitogen-stimulated mononuclear cells or on concentrations of cytokines (interleukin 2, interferon , and interleukin 1ß) in feces. Among the antigen [lipopolysaccharide and invasion plasmid-encoded antigen (Ipa)]-specific antibodies, plasma Ipa-specific immunoglobulin G responses at day 30 were significantly higher in the zinc group than in the control group. However, the 2 groups did not differ significantly in the other antigen-specific responses in plasma and stool.
Conclusion: A 14-d course of zinc supplementation during acute shigellosis increases the lymphocyte proliferation response and the Ipa-specific immunoglobulin G response.
Key Words: Zinc • Shigella • specific immunity • cellular immunity
This article has been cited by other articles:
|
|
 |
|
  J. Carcillo, R. Holubkov, J. M. Dean, J. Berger, K. L. Meert, K. J. S. Anand, J. Zimmerman, C. J. L. Newth, R. Harrison, D. F. Willson, et al. Rationale and Design of the Pediatric Critical Illness Stress-Induced Immune Suppression (CRISIS) Prevention Trial JPEN J Parenter Enteral Nutr, July 1, 2009; 33(4): 368 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Raqib, D. S Alam, P. Sarker, S. M. Ahmad, G. Ara, M. Yunus, S. E Moore, and G. Fuchs Low birth weight is associated with altered immune function in rural Bangladeshi children: a birth cohort study Am. J. Clinical Nutrition, March 1, 2007; 85(3): 845 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Qadri, A.-M. Svennerholm, A. S. G. Faruque, and R. B. Sack Enterotoxigenic Escherichia coli in Developing Countries: Epidemiology, Microbiology, Clinical Features, Treatment, and Prevention Clin. Microbiol. Rev., July 1, 2005; 18(3): 465 - 483. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J Rahman, P. Sarker, S. K Roy, S. M Ahmad, J. Chisti, T. Azim, M. Mathan, D. Sack, J. Andersson, and R. Raqib Effects of zinc supplementation as adjunct therapy on the systemic immune responses in shigellosis Am. J. Clinical Nutrition, February 1, 2005; 81(2): 495 - 502. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
