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COMMENTARY |
1 From the Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA (GAB), and the Department of Nutrition, University of North Carolina, Chapel Hill (SJN and BMP).
Obesity is a major epidemic, but its causes are still unclear. In this article, we investigate the relation between the intake of high-fructose corn syrup (HFCS) and the development of obesity. We analyzed food consumption patterns by using US Department of Agriculture food consumption tables from 1967 to 2000. The consumption of HFCS increased > 1000% between 1970 and 1990, far exceeding the changes in intake of any other food or food group. HFCS now represents > 40% of caloric sweeteners added to foods and beverages and is the sole caloric sweetener in soft drinks in the United States. Our most conservative estimate of the consumption of HFCS indicates a daily average of 132 kcal for all Americans aged 
2 y, and the top 20% of consumers of caloric sweeteners ingest 316 kcal from HFCS/d. The increased use of HFCS in the United States mirrors the rapid increase in obesity. The digestion, absorption, and metabolism of fructose differ from those of glucose. Hepatic metabolism of fructose favors de novo lipogenesis. In addition, unlike glucose, fructose does not stimulate insulin secretion or enhance leptin production. Because insulin and leptin act as key afferent signals in the regulation of food intake and body weight, this suggests that dietary fructose may contribute to increased energy intake and weight gain. Furthermore, calorically sweetened beverages may enhance caloric overconsumption. Thus, the increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of HFCS in calorically sweetened beverages may play a role in the epidemic of obesity.
Key Words: Epidemiology • food intake • obesity • artificial sweeteners • fructose
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|
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|
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|
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|
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|
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|
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|
|
|
|
 |
|
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|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
|
|
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|
|
|
|
 |
|
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|
|
|
|
 |
|
 M. N. Feinglos and S. E. Totten Are You What You Eat, or How Much You Eat?: The Case of Type 2 Diabetes Mellitus Arch Intern Med, July 28, 2008; 168(14): 1485 - 1486. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
 |
|
 S. K. Kumanyika, E. Obarzanek, N. Stettler, R. Bell, A. E. Field, S. P. Fortmann, B. A. Franklin, M. W. Gillman, C. E. Lewis, W. C. Poston II, et al. Population-Based Prevention of Obesity: The Need for Comprehensive Promotion of Healthful Eating, Physical Activity, and Energy Balance: A Scientific Statement From American Heart Association Council on Epidemiology and Prevention, Interdisciplinary Committee for Prevention (Formerly the Expert Panel on Population and Prevention Science) Circulation, July 22, 2008; 118(4): 428 - 464. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. H. Adams, K. L. Stanhope, R. W. Grant, B. P. Cummings, and P. J. Havel Metabolic and Endocrine Profiles in Response to Systemic Infusion of Fructose and Glucose in Rhesus Macaques Endocrinology, June 1, 2008; 149(6): 3002 - 3008. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
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|
|
|
|
|
|
S. Kirchner, A. Muduli, D. Casirola, K. Prum, V. Douard, and R. P Ferraris Luminal fructose inhibits rat intestinal sodium-phosphate cotransporter gene expression and phosphate uptake Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1028 - 1038. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A Bray Reply to RJ Hine and JS White Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1064 - 1065. [Full Text] [PDF]
|
|
|
|
|
|
J. S White No unique role for fructose sweeteners in obesity or cardiorenal disease Am. J. Clinical Nutrition, April 1, 2008; 87(4): 1062 - 1063. [Full Text] [PDF]
|
|
|
|
 |
|
 L. G. Sanchez-Lozada, E. Tapia, P. Bautista-Garcia, V. Soto, C. Avila-Casado, I. P. Vega-Campos, T. Nakagawa, L. Zhao, M. Franco, and R. J. Johnson Effects of febuxostat on metabolic and renal alterations in rats with fructose-induced metabolic syndrome Am J Physiol Renal Physiol, April 1, 2008; 294(4): F710 - F718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Brown, A. G. Dulloo, G. Yepuri, and J.-P. Montani Fructose ingestion acutely elevates blood pressure in healthy young humans Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R730 - R737. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Underwood Sugary drinks, fruit, and increased risk of gout BMJ, February 9, 2008; 336(7639): 285 - 286. [Full Text] [PDF]
|
|
|
|
|
|
H. K Choi and G. Curhan Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study BMJ, February 9, 2008; 336(7639): 309 - 312. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Harrington The Role of Sugar-Sweetened Beverage Consumption in Adolescent Obesity: A Review of the Literature The Journal of School Nursing, February 1, 2008; 24(1): 3 - 12. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. C. Cave, R. T. Hurt, T. H. Frazier, P. J. Matheson, R. N. Garrison, C. J. McClain, and S. A. McClave Obesity, Inflammation, and the Potential Application of Pharmaconutrition Nutr Clin Pract, February 1, 2008; 23(1): 16 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cao, H. Lu, T. L. Lewis, and L. Li Intake of Sucrose-sweetened Water Induces Insulin Resistance and Exacerbates Memory Deficits and Amyloidosis in a Transgenic Mouse Model of Alzheimer Disease J. Biol. Chem., December 14, 2007; 282(50): 36275 - 36282. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G H. Anderson Much ado about high-fructose corn syrup in beverages: the meat of the matter Am. J. Clinical Nutrition, December 1, 2007; 86(6): 1577 - 1578. [Full Text] [PDF]
|
|
|
|
|
|
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|
|
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T. Akhavan and G H. Anderson Effects of glucose-to-fructose ratios in solutions on subjective satiety, food intake, and satiety hormones in young men Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1354 - 1363. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Yasuda, R. Maiorano, R. M. Welch, D. D. Miller, and X. G. Lei Cecum Is the Major Degradation Site of Ingested Inulin in Young Pigs J. Nutr., November 1, 2007; 137(11): 2399 - 2404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. A Bray How bad is fructose? Am. J. Clinical Nutrition, October 1, 2007; 86(4): 895 - 896. [Full Text] [PDF]
|
|
|
|
|
|
R. J Johnson, M. S Segal, Y. Sautin, T. Nakagawa, D. I Feig, D.-H. Kang, M. S Gersch, S. Benner, and L. G Sanchez-Lozada Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease Am. J. Clinical Nutrition, October 1, 2007; 86(4): 899 - 906. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Aeberli, M. B Zimmermann, L. Molinari, R. Lehmann, D. l'Allemand, G. A Spinas, and K. Berneis Fructose intake is a predictor of LDL particle size in overweight schoolchildren Am. J. Clinical Nutrition, October 1, 2007; 86(4): 1174 - 1178. [Abstract] [Full Text] [PDF]
|
|
|
|
|
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E. G. Neilson The Fructose Nation J. Am. Soc. Nephrol., October 1, 2007; 18(10): 2619 - 2621. [Full Text] [PDF]
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|
|
|
|
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|
|
|
|
|
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|
|
 |
|
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|
|
|
|
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