HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Baer, D. J Articles by Tracy, R. P Search for Related Content PubMed PubMed Citation Articles by Baer, D. J Articles by Tracy, R. P Agricola Articles by Baer, D. J Articles by Tracy, R. P

Dietary fatty acids affect plasma markers of inflammation in healthy men fed controlled diets: a randomized crossover study^1,2,3

¹ From the Diet and Human Performance Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, Beltsville, MD (DJB, JTJ, and BAC), and the Departments of Pathology and Biochemistry, the University of Vermont, College of Medicine, Burlington, VT (RPT).

Background: The effect of individual dietary fatty acids on emerging risk factors for cardiovascular disease that are associated with subclinical inflammation is unknown.

Objective: The goal was to evaluate the role of dietary fat and specific fatty acids, especially trans fatty acids, in altering concentrations of markers of inflammation in humans fed controlled diets.

Design: In a randomized crossover design, 50 men consumed controlled diets for 5 wk that provided 15% of energy from protein, 39% of energy from fat, and 46% of energy from carbohydrate. Eight percent of fat or fatty acids was replaced across diets with the following: cholesterol, oleic acid, trans fatty acids (TFAs), stearic acid (STE), TFA+STE (4% of energy each), and 12:0–16:0 saturated fatty acids (LMP).

Results: Fibrinogen concentrations were higher after consumption of the diet enriched in stearic acid than after consumption of the carbohydrate diet. C-reactive protein concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet, but were not significantly different after consumption of the TFA and TFA+STE diets than after consumption of the LMP diet. Interleukin 6 concentrations were lower after consumption of the oleic acid diet than after consumption of the LMP, TFA, and STE diets. E-selectin concentrations were higher after consumption of the TFA diet than after consumption of the carbohydrate diet. Consumption of the TFA but not the TFA+STE diet resulted in higher E-selectin concentrations than did the LMP diet.

Conclusions: These data provide evidence that dietary fatty acids can modulate markers of inflammation. Although stearic acid minimally affects LDL cholesterol, it does appear to increase fibrinogen concentrations.

Key Words: Inflammation • trans fatty acids • dietary fat • interleukins • cell adhesion molecules

This article has been cited by other articles:

				T. Tholstrup, M. Raff, E. M. Straarup, P. Lund, S. Basu, and J. M. Bruun An Oil Mixture with Trans-10, Cis-12 Conjugated Linoleic Acid Increases Markers of Inflammation and in Vivo Lipid Peroxidation Compared with Cis-9, Trans-11 Conjugated Linoleic Acid in Postmenopausal Women J. Nutr., August 1, 2008; 138(8): 1445 - 1451. [Abstract] [Full Text] [PDF]

				J. A Nettleton, M. B Schulze, R. Jiang, N. S Jenny, G. L Burke, and D. R Jacobs Jr A priori-defined dietary patterns and markers of cardiovascular disease risk in the Multi-Ethnic Study of Atherosclerosis (MESA) Am. J. Clinical Nutrition, July 1, 2008; 88(1): 185 - 194. [Abstract] [Full Text] [PDF]

				A. Motard-Belanger, A. Charest, G. Grenier, P. Paquin, Y. Chouinard, S. Lemieux, P. Couture, and B. Lamarche Study of the effect of trans fatty acids from ruminants on blood lipids and other risk factors for cardiovascular disease Am. J. Clinical Nutrition, March 1, 2008; 87(3): 593 - 599. [Abstract] [Full Text] [PDF]

				J. Delgado-Lista, J. Lopez-Miranda, B. Cortes, P. Perez-Martinez, A. Lozano, R. Gomez-Luna, P. Gomez, M. J. Gomez, J. Criado, F. Fuentes, et al. Chronic dietary fat intake modifies the postprandial response of hemostatic markers to a single fatty test meal Am. J. Clinical Nutrition, February 1, 2008; 87(2): 317 - 322. [Abstract] [Full Text] [PDF]

				J. E. Chavarro, M. J. Stampfer, H. Campos, T. Kurth, W. C. Willett, and J. Ma A Prospective Study of Trans-Fatty Acid Levels in Blood and Risk of Prostate Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2008; 17(1): 95 - 101. [Abstract] [Full Text] [PDF]

				X. Liu, F. R. Schumacher, S. J. Plummer, E. Jorgenson, G. Casey, and J. S. Witte trans-Fatty acid intake and increased risk of advanced prostate cancer: modification by RNASEL R462Q variant Carcinogenesis, June 1, 2007; 28(6): 1232 - 1236. [Abstract] [Full Text] [PDF]

				K. S Stote, D. J Baer, K. Spears, D. R Paul, G K. Harris, W. V Rumpler, P. Strycula, S. S Najjar, L. Ferrucci, D. K Ingram, et al. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults Am. J. Clinical Nutrition, April 1, 2007; 85(4): 981 - 988. [Abstract] [Full Text] [PDF]

				L. J. Ignarro, M. L. Balestrieri, and C. Napoli Nutrition, physical activity, and cardiovascular disease: An update Cardiovasc Res, January 15, 2007; 73(2): 326 - 340. [Abstract] [Full Text] [PDF]

				J. E Chavarro, J. W Rich-Edwards, B. A Rosner, and W. C Willett Dietary fatty acid intakes and the risk of ovulatory infertility Am. J. Clinical Nutrition, January 1, 2007; 85(1): 231 - 237. [Abstract] [Full Text] [PDF]

				M.D KONTOGIANNI, A ZAMPELAS, and C TSIGOS Nutrition and Inflammatory Load Ann. N.Y. Acad. Sci., November 1, 2006; 1083(1): 214 - 238. [Abstract] [Full Text] [PDF]

				D. Giugliano, A. Ceriello, and K. Esposito The Effects of Diet on Inflammation: Emphasis on the Metabolic Syndrome J. Am. Coll. Cardiol., August 15, 2006; 48(4): 677 - 685. [Abstract] [Full Text] [PDF]

				R. N. Lemaitre, I. B. King, D. Mozaffarian, N. Sotoodehnia, T. D. Rea, L. H. Kuller, R. P. Tracy, and D. S. Siscovick Plasma Phospholipid Trans Fatty Acids, Fatal Ischemic Heart Disease, and Sudden Cardiac Death in Older Adults: The Cardiovascular Health Study Circulation, July 18, 2006; 114(3): 209 - 215. [Abstract] [Full Text] [PDF]

				A. Basu, S. Devaraj, and I. Jialal Dietary Factors That Promote or Retard Inflammation Arterioscler. Thromb. Vasc. Biol., May 1, 2006; 26(5): 995 - 1001. [Abstract] [Full Text] [PDF]

				D. Mozaffarian, M. B. Katan, A. Ascherio, M. J. Stampfer, and W. C. Willett Trans Fatty Acids and Cardiovascular Disease N. Engl. J. Med., April 13, 2006; 354(15): 1601 - 1613. [Full Text] [PDF]

				S. E Kasim-Karakas, A. Tsodikov, U. Singh, and I. Jialal Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 774 - 779. [Abstract] [Full Text] [PDF]

				S. Desroches, W. R. Archer, M.-E. Paradis, O. Deriaz, P. Couture, J. Bergeron, N. Bergeron, and B. Lamarche Baseline Plasma C-Reactive Protein Concentrations Influence Lipid and Lipoprotein Responses to Low-Fat and High Monounsaturated Fatty Acid Diets in Healthy Men J. Nutr., April 1, 2006; 136(4): 1005 - 1011. [Abstract] [Full Text] [PDF]

				T. Tholstrup, M. Raff, S. Basu, P. Nonboe, K. Sejrsen, and E. M Straarup Effects of butter high in ruminant trans and monounsaturated fatty acids on lipoproteins, incorporation of fatty acids into lipid classes, plasma C-reactive protein, oxidative stress, hemostatic variables, and insulin in healthy young men Am. J. Clinical Nutrition, February 1, 2006; 83(2): 237 - 243. [Abstract] [Full Text] [PDF]

				M. A.M.A. Thijssen, G. Hornstra, and R. P. Mensink Stearic, Oleic, and Linoleic Acids Have Comparable Effects on Markers of Thrombotic Tendency in Healthy Human Subjects J. Nutr., December 1, 2005; 135(12): 2805 - 2811. [Abstract] [Full Text] [PDF]

				T. T Fung, M. L McCullough, P. Newby, J. E Manson, J. B Meigs, N. Rifai, W. C Willett, and F. B Hu Diet-quality scores and plasma concentrations of markers of inflammation and endothelial dysfunction Am. J. Clinical Nutrition, July 1, 2005; 82(1): 163 - 173. [Abstract] [Full Text] [PDF]

				K. F. Hilpert, P. M. Kris-Etherton, and S. G. West Lipid Response to a Low-Fat Diet with or without Soy Is Modified by C-Reactive Protein Status in Moderately Hypercholesterolemic Adults J. Nutr., May 1, 2005; 135(5): 1075 - 1079. [Abstract] [Full Text] [PDF]

				I. B. King, A. R. Kristal, S. Schaffer, M. Thornquist, and G. E. Goodman Serum Trans-Fatty Acids Are Associated with Risk of Prostate Cancer in {beta}-Carotene and Retinol Efficacy Trial Cancer Epidemiol. Biomarkers Prev., April 1, 2005; 14(4): 988 - 992. [Abstract] [Full Text] [PDF]

				E. Lopez-Garcia, M. B. Schulze, J. B. Meigs, J. E. Manson, N. Rifai, M. J. Stampfer, W. C. Willett, and F. B. Hu Consumption of Trans Fatty Acids Is Related to Plasma Biomarkers of Inflammation and Endothelial Dysfunction J. Nutr., March 1, 2005; 135(3): 562 - 566. [Abstract] [Full Text] [PDF]

				D. Mozaffarian, E. B Rimm, I. B King, R. L Lawler, G. B McDonald, and W. C Levy trans Fatty acids and systemic inflammation in heart failure Am. J. Clinical Nutrition, December 1, 2004; 80(6): 1521 - 1525. [Abstract] [Full Text] [PDF]