AJCN Tufts Nutrition Symposium, Boston Sept 24-26
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American Journal of Clinical Nutrition, Vol 8, 259-264, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

The Disappearance of Intravenously Administered Vitamin B12

Studies in Normal Subjects and in Patients with Pernicious Anemia

SOLOMON ESTREN M.D.1, EUGENE A. BRODY M.D.1, and LOUIS R. WASSERMAN M.D.1

1 From the Department of Hematology, The Mount Sinai Hospital, New York, New York

The fate of radioactive vitamin B12 following its intravenous injection was determined in normal subjects and in patients with chronic myelocytic leukemia and pernicious anemia.

The resulting plasma disappearance curves were abnormal patients with chronic myelocytic leukemia and pernicious anemia.

The abnormally slow plasma clearance of vitamin B12 found in pernicious anemia persisted even in patients in complete hematologic and clinical remission.

The concept of a circulating "serum B12-transferase" is suggested to explain these findings.






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Copyright © 1960 by The American Society for Nutrition