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American Journal of Clinical Nutrition, Vol 8, 297-300, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

The Relation of Binding Power to Intrinsic Factor Activity

Effect of Pseudovitamin B12 on Absorption of Vitamin B12

MILTON TOPOREK PH.D.1

1 From the Thomas Henry Simpson Memorial Institute for Medical Research, The University of Michigan, Ann Arbor, Michigan

Evidence is presented to show that binding is an essential property for intrinsic factor activity.

Exchange between bound and free vitamin B12 in normal human gastric juice is slow or negligible under conditions of these experiments.

Intrinsic factor preferentially binds vitamin B12 in the presence of pseudovitamin B12.




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H. B. Barner, T. I. Jones, and T. B. Garlick
Temporary Impairment of Vitamin B12 Absorption: Another Side Effect of Therapeutic Gastric Freezing
JAMA, November 23, 1964; 190(8): 779 - 781.
[Abstract] [PDF]


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Copyright © 1960 by The American Society for Nutrition