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American Journal of Clinical Nutrition, Vol 8, 306-309, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

Lipotropic Agents and Lipid Transport

W. E. CORNATZER M.D., PH.D.1

1 From the Department of Biochemistry, University of North Dakota, Grand Forks, North Dakota

The lipotropic action of choline, betaine, inositol, methionine and dietary proteins is discussed.

The lipotropic action of choline shows its effect not only in the liver but also in other tissues, such as kidney, aorta and other blood vessels. Phospholipids containing choline are involved in this lipotropic process, effecting primarily the mitochondria and large granules in the liver cell.

The effect of a single dose of lipotropic agent is chiefly due to the increased rate of formation of lecithins. In cirrhotic patients with fatty infiltration in the liver, a significant increase in the rate of phospholipid synthesis was demonstrated by biopsy after a single dose of choline or intravenous administration of methionine. This stimulating effect of lipid phosphorylation by lipotropic agents does not occur in experimental animals maintained on stock diet or in man on an adequate protein intake.






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Copyright © 1960 by The American Society for Nutrition