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American Journal of Clinical Nutrition, Vol 8, 562-568, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

Satiety Signals

MORTON I. GROSSMAN M.D., PH.D.1

1 From the Wadsworth Veterans Hospital and Departments of Medicine and Physiology, University of California, Los Angeles, California

Many factors are concerned in the production of satiety or cessation of eating. Among these are a stomach distended either by food or non-nutritious substances and, over a relatively long period of time, energy balance. On the other hand, food that has left the stomach, secretion of enterogastrone, or large amounts of intravenous glucose appear to have no effects on satiety. Although it has been postulated that the inhibition of feeding reflexes are carried through the hypothalamic portion of the brain, neither the precise pathways that mediate satiety nor the interrelation of the many factors causing cessation of eating are known.




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A. V. Schally, T. W. Redding, H. W. Lucien, and J. Meyer
Enterogastrone Inhibits Eating by Fasted Mice
Science, July 14, 1967; 157(3785): 210 - 211.
[Abstract] [PDF]


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