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American Journal of Clinical Nutrition, Vol 8, 645-650, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

The Homeostatic Control of Cholesterol Synthesis in Liver

MARVIN D. SIPERSTEIN M.D., PH.D.1

1 From the Department of Internal Medicine, The University of Texas Southwestern Medical School, Dallas, Texas

The feedback mechanism by which cholesterol synthesis is regulated in liver has been studied. Evidence has been presented which indicates that exogenous cholesterol inhibits cholesterol synthesis primarily by blocking the conversion of beta-hydroxy-beta-methylglutaryl CoA to mevalonic acid. This reaction would appear to represent the major biochemical site of normal homeostatic control of cholesterol synthesis in the liver. This inhibition of cholesterol synthesis does not appear to be directly mediated by cholesterol itself, the common cholesterol esters, or taurocholic acid. The exact mechanism by which cholesterol feeding inhibits the conversion of beta-hydroxy-beta-methylglutaryl CoA to mevalonate remains to be elucidated.






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Copyright © 1960 by The American Society for Nutrition