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American Journal of Clinical Nutrition, Vol 8, 733-739, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

Factors Concerned with the Regulation of Fatty Acid Metabolism by Adipose Tissue

GEORGE F. CAHILL JR. M.D.1, BERNARD LEBOEUF M.D.1, and ALBERT E. RENOLD M.D.1

1 From the Departments of Medicine, Harvard Medical School and the Peter Bent Brigham Hospital and the Baker Clinic Research Laboratory, New England Deaconess Hospital, Boston, Massachusetts

The rate of fatty acid release by adipose tissue is dependent on the relative rates of fatty acid esterification and lipolysis. Glucose is necessary for the esterification process, probably due to glycerolphosphate formation. Epinephrine and other hormones which accelerate fatty acid release appear to affect the rate of lipolysis. As glucose uptake is diminished, glyceride-glycerol formation becomes the major metabolic product of glucose utilization. As glucose uptake is increased, after glyceride-glycerol synthesis becomes sufficient to esterify the fatty acids, the surplus metabolized glucose is utilized for lipogenesis.




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Overexpression of 1-Acyl-Glycerol-3-Phosphate Acyltransferase-{alpha} Enhances Lipid Storage in Cellular Models of Adipose Tissue and Skeletal Muscle
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[Abstract] [Full Text]




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