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American Journal of Clinical Nutrition, Vol 8, 767-774, Copyright © 1960 by The American Society for Clinical Nutrition, Inc.

Overfeeding as a Stress

GORDON C. KENNEDY M.B., PH.D.1

1 From the Medical Research Council, Department of Experimental Medicine, University of Cambridge, Cambridge, England

Apart from adiposity, overnutrition causes metabolic and structural adaptations in a variety of tissues. Although initially beneficial, such adaptation may finally predispose to pathologic changes. It is suggested that prolonged overproduction of insulin may be a factor in the increased incidence of diabetes in obesity. Possible causes for abnormal tubular hyperplasia observed in the kidneys of obese rats are considered in relation to the frequency of renal diseases in the obese animals.






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Copyright © 1960 by The American Society for Nutrition