| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Epidemiology, Institute of Public Health, University of Copenhagen (HF); the Blair Research Laboratory, Ministry of Health, Harare, Zimbabwe (EG); the Department of Immunology, University of Zimbabwe, Harare, Zimbabwe (EG); the Department of Clinical Pharmacology, University of Zimbabwe, Harare, Zimbabwe (NN); the Department of Medical Laboratory Sciences, University of Zimbabwe, Harare, Zimbabwe (PN); the Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark (HK); and the Department of Human Nutrition, Royal Veterinary and Agricultural University, Frederiksberg, Denmark (PK and KFM)
Background: Multiple micronutrient deficiencies may contribute to low birth weight, which is a major global determinant of mortality.
Objective: We assessed the effect of prenatal multimicronutrient supplementation on gestational length and birth size.
Design: We conducted a randomized, placebo-controlled, double-blind effectiveness trial among antenatal care attendees in Harare, Zimbabwe. Pregnant women (22–35 wk of gestation) were randomly allocated to receive a multimicronutrient or placebo supplement daily until delivery. Supplementation with iron and folic acid was part of antenatal care.
Results: Of 1669 women, birth data were available from 1106 (66%), of whom 360 (33%) had HIV infection. The mean gestational length was 39.1 wk, and 16.6% of the women had a gestational length < 37 wk. The mean birth weight was 3030 g, and 10.5% of the infants had a birth weight < 2500 g. Multimicronutrient supplementation was associated with tendencies for increased gestational length (0.3 wk; 95% CI: –0.04, 0.6 wk; P = 0.06), birth weight (49 g; –6, 104 g; P = 0.08), and head circumference (0.2 cm; –0.02, 0.4 cm; P = 0.07) but was not associated with low birth weight (birth weight < 2500 g) (relative risk: 0.84; 0.59, 1.18; P = 0.31). The effect of multimicronutrient supplementation on birth weight was not significantly different between HIV-uninfected (26 g; –38, 91 g) and HIV-infected (101 g; –3, 205 g) subjects (interaction, P > 0.10).
Conclusion: Antenatal multimicronutrient supplementation may be one strategy to increase birth size.
Key Words: Pregnancy • micronutrient supplementation • HIV • gestational length • birth size • low birth weight • Zimbabwe
This article has been cited by other articles:
|
|
 |
|
  K. Kawai, R. Kupka, F. Mugusi, S. Aboud, J. Okuma, E. Villamor, D. Spiegelman, and W. W Fawzi A randomized trial to determine the optimal dosage of multivitamin supplements to reduce adverse pregnancy outcomes among HIV-infected women in Tanzania Am. J. Clinical Nutrition, February 1, 2010; 91(2): 391 - 397. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. P Stewart, P. Christian, S. C LeClerq, K. P West Jr, and S. K Khatry Antenatal supplementation with folic acid + iron + zinc improves linear growth and reduces peripheral adiposity in school-age children in rural Nepal Am. J. Clinical Nutrition, July 1, 2009; 90(1): 132 - 140. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. S. Shah, A. Ohlsson, and on behalf of the Knowledge Synthesis Group on Dete Effects of prenatal multimicronutrient supplementation on pregnancy outcomes: a meta-analysis Can. Med. Assoc. J., June 9, 2009; 180(12): E99 - E108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Q. Li, H. Yan, L. Zeng, Y. Cheng, W. Liang, S. Dang, Q. Wang, and I. Tsuji Effects of Maternal Multimicronutrient Supplementation on the Mental Development of Infants in Rural Western China: Follow-up Evaluation of a Double-Blind, Randomized, Controlled Trial Pediatrics, April 1, 2009; 123(4): e685 - e692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Roberfroid, L. Huybregts, H. Lanou, M.-C. Henry, N. Meda, J. Menten, P. Kolsteren, and for the MISAME Study Group Effects of maternal multiple micronutrient supplementation on fetal growth: a double-blind randomized controlled trial in rural Burkina Faso Am. J. Clinical Nutrition, November 1, 2008; 88(5): 1330 - 1340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Tofail, L. A. Persson, S. El Arifeen, J. D Hamadani, F. Mehrin, D. Ridout, E.-C. Ekstrom, S. N Huda, and S. M Grantham-McGregor Effects of prenatal food and micronutrient supplementation on infant development: a randomized trial from the Maternal and Infant Nutrition Interventions, Matlab (MINIMat) study Am. J. Clinical Nutrition, March 1, 2008; 87(3): 704 - 711. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S Palma, R Perez-Iglesias, D Prieto, R Pardo, J Llorca, and M Delgado-Rodriguez Iron but not folic acid supplementation reduces the risk of low birthweight in pregnant women without anaemia: a case control study J Epidemiol Community Health, February 1, 2008; 62(2): 120 - 124. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. W. Fawzi, G. I. Msamanga, W. Urassa, E. Hertzmark, P. Petraro, W. C. Willett, and D. Spiegelman Vitamins and Perinatal Outcomes among HIV-Negative Women in Tanzania N. Engl. J. Med., April 5, 2007; 356(14): 1423 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Gupta, M. Ray, T. Dua, G. Radhakrishnan, R. Kumar, and H. P. S. Sachdev Multimicronutrient Supplementation for Undernourished Pregnant Women and the Birth Size of Their Offspring: A Double-blind, Randomized, Placebo-Controlled Trial Arch Pediatr Adolesc Med, January 1, 2007; 161(1): 58 - 64. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. A. Haws and G. L. Darmstadt Integrated, Evidence-Based Approaches to Save Newborn Lives in Developing Countries Arch Pediatr Adolesc Med, January 1, 2007; 161(1): 99 - 102. [Full Text] [PDF]
|
|
|
|
|
|
I. Darnton-Hill, P. Webb, P. W. Harvey, J. M Hunt, N. Dalmiya, M. Chopra, M. J Ball, M. W Bloem, and B. de Benoist Micronutrient deficiencies and gender: social and economic costs Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1198S - 1205S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Weedon, T. M. Frayling, B. Shields, B. Knight, T. Turner, B. S. Metcalf, L. Voss, T. J. Wilkin, A. McCarthy, Y. Ben-Shlomo, et al. Genetic Regulation of Birth Weight and Fasting Glucose by a Common Polymorphism in the Islet Cell Promoter of the Glucokinase Gene Diabetes, February 1, 2005; 54(2): 576 - 581. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
