| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Institut National de la Santé et de la Recherche Médicale (INSERM) Research Unit 403, Hôpital Edouard Herriot, Lyon, France (PS, FD, and PDD), and the Société de Secours Minière de Bourgogne (SSMB), Montceau les Mines, France (FM)
Background: Aging-related sarcopenia is characterized by a loss of muscle mass and strength and increased fatigability. However, studies of its determinants in elderly men are scarce.
Objective: We investigated risk factors for sarcopenia in a large cohort of men.
Design: We analyzed 845 men aged 45–85 y who belonged to the MINOS cohort. Lifestyle factors (physical activity, tobacco smoking, alcohol intake, caffeine intake) were evaluated by using a standardized questionnaire. Appendicular skeletal muscle mass (ASM) was estimated by using dual-energy X-ray absorptiometry. The relative appendicular skeletal muscle mass index (RASM) was calculated as ASM/body height2.3. Apparent free testosterone concentration (AFTC) and free testosterone index (FTI) were calculated on the basis of concentrations of total testosterone and sex hormone–binding globulin.
Results: RASM decreased with age (r = –0.29, P < 0.0001). Current smokers had lower RASM than did subjects who never smoked (–3.2%; P < 0.003). RASM increased with the intensity of physical activity at work (P for trend < 0.001). Men who participated in regular exercise during leisure time had 2.2% higher RASM than did those who did not (P < 0.03). Men whose values for AFTC, FTI, or 25-hydroxycholecalciferol [25(OH)D] were >2 SDs below the mean for young men had significantly lower RASM than did men with higher values. Men with sarcopenia, defined as the lowest quartile of RASM in the studied cohort (<6.32 kg/m2.3), were significantly older than men with normal RASM, weighed significantly less, smoked more, and spent significantly less time on leisure-time activities. Sarcopenic men also had lower values for testosterone, AFTC, FTI, and 25(OH)D.
Conclusion: In elderly men, low physical activity, tobacco smoking, thinness, low testosterone (AFTC and FTI), and decreased 25(OH)D concentrations are risk factors for sarcopenia.
Key Words: Sarcopenia • appendicular skeletal muscle mass • physical activity • tobacco smoking • testosterone • 25-hydroxycholecalciferol • men
This article has been cited by other articles:
|
|
 |
|
  E. S. LeBlanc, C. M. Nielson, L. M. Marshall, J. A. Lapidus, E. Barrett-Connor, K. E. Ensrud, A. R. Hoffman, G. Laughlin, C. Ohlsson, E. S. Orwoll, et al. The Effects of Serum Testosterone, Estradiol, and Sex Hormone Binding Globulin Levels on Fracture Risk in Older Men J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3337 - 3346. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. B. Lushaj, J. K. Johnson, D. McKenzie, and J. M. Aiken Sarcopenia Accelerates at Advanced Ages in Fisher 344xBrown Norway Rats J. Gerontol. A Biol. Sci. Med. Sci., September 1, 2008; 63(9): 921 - 927. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Kronborg, M. Solbu, I. Njolstad, I. Toft, B. O. Eriksen, and T. Jenssen Predictors of change in estimated GFR: a population-based 7-year follow-up from the Tromso study Nephrol. Dial. Transplant., September 1, 2008; 23(9): 2818 - 2826. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Marzetti, L. Groban, S. E. Wohlgemuth, H. A. Lees, M. Lin, H. Jobe, S. Giovannini, C. Leeuwenburgh, and C. S. Carter Effects of short-term GH supplementation and treadmill exercise training on physical performance and skeletal muscle apoptosis in old rats Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2008; 294(2): R558 - R567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Vandenput, D. Mellstrom, M. Lorentzon, C. Swanson, M. K. Karlsson, J. Brandberg, L. Lonn, E. Orwoll, U. Smith, F. Labrie, et al. Androgens and Glucuronidated Androgen Metabolites Are Associated with Metabolic Risk Factors in Men J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4130 - 4137. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. W. Petersen, F. Magkos, P. Atherton, A. Selby, K. Smith, M. J. Rennie, B. K. Pedersen, and B. Mittendorfer Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle Am J Physiol Endocrinol Metab, September 1, 2007; 293(3): E843 - E848. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Orwoll, L. C. Lambert, L. M. Marshall, J. Blank, E. Barrett-Connor, J. Cauley, K. Ensrud, S. R. Cummings, and for the Osteoporotic Fractures in Men Study Group Endogenous testosterone levels, physical performance, and fall risk in older men. Arch Intern Med, October 23, 2006; 166(19): 2124 - 2131. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Alfaro-Acha, S. A. Snih, M. A. Raji, Y.-F. Kuo, K. S. Markides, and K. J. Ottenbacher Handgrip strength and cognitive decline in older mexican americans. J. Gerontol. A Biol. Sci. Med. Sci., August 1, 2006; 61(8): 859 - 865. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Van Vliet, M. A. Spruit, G. Verleden, A. Kasran, E. Van Herck, F. Pitta, R. Bouillon, and M. Decramer Hypogonadism, Quadriceps Weakness, and Exercise Intolerance in Chronic Obstructive Pulmonary Disease Am. J. Respir. Crit. Care Med., November 1, 2005; 172(9): 1105 - 1111. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D Hansen Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS Study Am. J. Clinical Nutrition, May 1, 2005; 81(5): 1180 - 1181. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
