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Cosupplementation with vitamin E and coenzyme Q₁₀ reduces circulating markers of inflammation in baboons^1,2,3

¹ From the Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX (XLW, DLR, and MCM); the Division of Cardiothoracic Surgery, Michael E DeBakey Department of Surgery, Baylor College of Medicine, Houston (XLW); the Southwest National Primate Research Center, San Antonio, TX (MCM); and the Centre for Vascular Research, School of Medical Sciences, University of New South Wales, and the Department of Haematology, Prince of Wales Hospital, Sydney, Australia (RS)

Background: Inflammation and oxidative stress are processes that mark early metabolic abnormalities in vascular diseases.

Objectives: We explored the effects of a high-fat, high-cholesterol (HFHC) diet on vascular responses in baboons and the potential response-attenuating effects of vitamin E and coenzyme Q₁₀ (CoQ₁₀) supplementation.

Design: We used a longitudinal design by subjecting 21 baboons (Papio hamadryas) to sequential dietary challenges.

Results: After being maintained for 3 mo on a baseline diet (low in fat and cholesterol), 21 baboons were challenged with an HFHC diet for 7 wk. The serum C-reactive protein (CRP) concentrations did not change. Subsequent supplementation of the HFHC diet with the antioxidant vitamin E (250, 500, or 1000 IU/kg diet) for 2 wk reduced serum CRP concentrations from 0.91 ± 0.02 to 0.43 ± 0.06 mg/dL. Additional supplementation with CoQ₁₀ (2 g/kg diet) further reduced serum CRP to 30% of baseline (0.28 ± 0.03 mg/dL; P = 0.036 compared with the HFHC diet). Introduction of the HFHC diet itself significantly decreased serum P-selectin (from 48.8 ± 7.2 to 32.9 ± 3.7 ng/dL, P = 0.02) and von Willebrand factor (from 187.0 ± 10.1 to 161.9 ± 9.0%, P = 0.02) concentrations. However, neither vitamin E alone nor vitamin E plus CoQ₁₀ significantly altered the serum concentrations of P-selectin or von Willebrand factor.

Conclusions: Dietary supplementation with vitamin E alone reduces the baseline inflammatory status that is indicated by the CRP concentration in healthy adult baboons. Cosupplementation with CoQ₁₀, however, significantly enhances this antiinflammatory effect of vitamin E.

Key Words: Atherosclerosis • oxygen radicals • cytokines • endothelial function • antioxidants

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				D. L Rainwater, M. C Mahaney, J. L VandeBerg, and X. L. Wang Vitamin E dietary supplementation significantly affects multiple risk factors for cardiovascular disease in baboons Am. J. Clinical Nutrition, September 1, 2007; 86(3): 597 - 603. [Abstract] [Full Text] [PDF]

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