| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia
Background: Gastric distension reduces food intake, and antral, rather than proximal, gastric distension may be the dominant mechanism in the induction of appetite-related sensations. Healthy aging is associated with reduced appetite.
Objective: We examined the effects of different energy preloads on appetite, plasma cholecystokinin, antral area, and subsequent energy intake in healthy older and young subjects.
Design: On 3 separate days, 12 young and 12 older subjects consumed 400 mL of a drink containing either 0 kcal (water), 250 kcal, or 750 kcal 70 min before a buffet-style meal.
Results: Hunger was less in the older than in the young subjects (P < 0.001). Both nutrient preloads reduced hunger and increased fullness more than did water (P < 0.02), and older subjects were more full than were the young (P < 0.05). Antral area was greater after the nutrient preloads than after water (P = 0.001) and greater in the older than in the young subjects (P = 0.005). In both groups, food intake was suppressed in an energy-dependent manner (P = 0.008). Plasma cholecystokinin was greater in the older than in the young subjects (P = 0.003). Immediately before the meal, hunger (r = –0.59) and energy intake (r = –0.90) were inversely related and fullness (r = 0.66) was directly related to antral area (all: P < 0.001). Antral area, but not plasma cholecystokinin, was a predictor of subsequent energy intake.
Conclusion: In healthy young and older subjects, the suppression of subsequent energy intake by a liquid preload is nutrient dependent and comparable, and both satiation and satiety are related to antral area and (presumably) antral distension.
Key Words: Antral area • energy intake • older subjects • young subjects • cholecystokinin
This article has been cited by other articles:
|
|
 |
|
  J. M. Bauer, A. Haack, K. Winning, R. Wirth, B. Fischer, W. Uter, J. Erdmann, V. Schusdziarra, and C. C. Sieber Impaired Postprandial Response of Active Ghrelin and Prolonged Suppression of Hunger Sensation in the Elderly J Gerontol A Biol Sci Med Sci, November 11, 2009; (2009) glp174v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. M. Brennan, K. L. Feltrin, N. S. Nair, T. Hausken, T. J. Little, D. Gentilcore, J. M. Wishart, K. L. Jones, M. Horowitz, and C. Feinle-Bisset Effects of the phases of the menstrual cycle on gastric emptying, glycemia, plasma GLP-1 and insulin, and energy intake in healthy lean women Am J Physiol Gastrointest Liver Physiol, September 1, 2009; 297(3): G602 - G610. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Farrell, F. Zamarripa, R. Shade, P. A. Phillips, M. McKinley, P. T. Fox, J. Blair-West, D. A. Denton, and G. F. Egan Effect of aging on regional cerebral blood flow responses associated with osmotic thirst and its satiation by water drinking: A PET study PNAS, January 8, 2008; 105(1): 382 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Little, K. L. Feltrin, M. Horowitz, J. H. Meyer, J. Wishart, I. M. Chapman, and C. Feinle-Bisset A high-fat diet raises fasting plasma CCK but does not affect upper gut motility, PYY, and ghrelin, or energy intake during CCK-8 infusion in lean men Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2008; 294(1): R45 - R51. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J Little, M. Horowitz, and C. Feinle-Bisset Modulation by high-fat diets of gastrointestinal function and hormones associated with the regulation of energy intake: implications for the pathophysiology of obesity Am. J. Clinical Nutrition, September 1, 2007; 86(3): 531 - 541. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. W. Apolzan, N. S. Carnell, R. D. Mattes, and W. W. Campbell Inadequate Dietary Protein Increases Hunger and Desire to Eat in Younger and Older Men J. Nutr., June 1, 2007; 137(6): 1478 - 1482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Gentilcore, R. Chaikomin, K. L. Jones, A. Russo, C. Feinle-Bisset, J. M. Wishart, C. K. Rayner, and M. Horowitz Effects of Fat on Gastric Emptying of and the Glycemic, Insulin, and Incretin Responses to a Carbohydrate Meal in Type 2 Diabetes J. Clin. Endocrinol. Metab., June 1, 2006; 91(6): 2062 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Little, A. N. Pilichiewicz, A. Russo, L. Phillips, K. L. Jones, M. A. Nauck, J. Wishart, M. Horowitz, and C. Feinle-Bisset Effects of Intravenous Glucagon-Like Peptide-1 on Gastric Emptying and Intragastric Distribution in Healthy Subjects: Relationships with Postprandial Glycemic and Insulinemic Responses J. Clin. Endocrinol. Metab., May 1, 2006; 91(5): 1916 - 1923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Gregersen, T. Hausken, J. Yang, S. Odegaard, and O. H. Gilja Mechanosensory properties in the human gastric antrum evaluated using B-mode ultrasonography during volume-controlled antral distension Am J Physiol Gastrointest Liver Physiol, May 1, 2006; 290(5): G876 - G882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. B. Roberts and I. Rosenberg Nutrition and Aging: Changes in the Regulation of Energy Metabolism With Aging Physiol Rev, April 1, 2006; 86(2): 651 - 667. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Di Francesco, M. Zamboni, A. Dioli, E. Zoico, G. Mazzali, F. Omizzolo, L. Bissoli, S. B. Solerte, L. Benini, and O. Bosello Delayed Postprandial Gastric Emptying and Impaired Gallbladder Contraction Together With Elevated Cholecystokinin and Peptide YY Serum Levels Sustain Satiety and Inhibit Hunger in Healthy Elderly Persons J Gerontol A Biol Sci Med Sci, December 1, 2005; 60(12): 1581 - 1585. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
