| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Nutrition and Dietetics, Harokopio University, Athens, Greece (AZ and DBP); and the First Cardiology Clinic, School of Medicine, University of Athens, Greece (CP, CC, and CS).
Background: The effect of coffee consumption on the cardiovascular system is conflicting. Inflammation is important to the development of cardiovascular disease (CVD), and several dietary factors are thought to exert significant effects on inflammation and thus on the risk of CVD.
Objective: We aimed to investigate the associations between coffee consumption and inflammatory markers.
Design: The cross-sectional survey enrolled 1514 men (
± SD age: 46 ± 13 y; range: 18–87 y) and 1528 women (aged 45 ± 13 y; range: 18–89 y). Five percent of men and 3% of women were excluded for history of CVD. Fasting blood samples were collected. Dietary habits (including consumption of various types of coffee) were evaluated by using a validated food-frequency questionnaire.
Results: Compared with coffee nondrinkers, men who consumed >200 mL coffee/d had 50% higher interleukin 6 (IL-6), 30% higher C-reactive protein (CRP), 12% higher serum amyloid-A (SAA), and 28% higher tumor necrosis factor 
(TNF-) concentrations and 3% higher white blood cell (WBC) counts (all: P < 0.05). Women who consumed >200 mL coffee/d had 54% higher IL-6, 38% higher CRP, 28% higher SAA, and 28% higher TNF- concentrations and 4% higher WBC counts (all: P < 0.05) than did coffee nondrinkers. The findings were significant even after control for the interactions between coffee consumption and age, sex, smoking, body mass index, physical activity status, and other covariates.
Conclusions: A relation exists between moderate-to-high coffee consumption and increased inflammation process. This relation could explain, in part, the effect of increased coffee intake on the cardiovascular system.
Key Words: Inflammation • cardiovascular disease • risk factors • coffee
This article has been cited by other articles:
|
|
 |
|
  J. K. MacLaine, A. B. M. Rabie, R. Wong, and A. Blechman Does orthodontic tooth movement cause an elevation in systemic inflammatory markers? Eur J Orthod, October 11, 2009; (2009) cjp108v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Lopez-Garcia, R. M van Dam, L. Qi, and F. B Hu Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women. Am. J. Clinical Nutrition, October 1, 2006; 84(4): 888 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Marsik, R. Sunder-Plassmann, B. Jilma, F. M. Kovar, C. Mannhalter, O. Wagner, H. Rumpold, and G. Endler The C-Reactive Protein +1444C/T Alteration Modulates the Inflammation and Coagulation Response in Human Endotoxemia Clin. Chem., October 1, 2006; 52(10): 1952 - 1957. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. F. Andersen, D. R Jacobs Jr, M. H Carlsen, and R. Blomhoff Consumption of coffee is associated with reduced risk of death attributed to inflammatory and cardiovascular diseases in the Iowa Women's Health Study Am. J. Clinical Nutrition, May 1, 2006; 83(5): 1039 - 1046. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Wieser, J.-L. Vigne, I. Ryan, D. Hornung, S. Djalali, and R. N. Taylor Sulindac Suppresses Nuclear Factor-{kappa}B Activation and RANTES Gene and Protein Expression in Endometrial Stromal Cells from Women with Endometriosis J. Clin. Endocrinol. Metab., December 1, 2005; 90(12): 6441 - 6447. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Vlachopoulos, D. Panagiotakos, N. Ioakeimidis, I. Dima, and C. Stefanadis Chronic coffee consumption has a detrimental effect on aortic stiffness and wave reflections Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1307 - 1312. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
