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Dual fortification of salt with iodine and micronized ferric pyrophosphate: a randomized, double-blind, controlled trial^1,2,3

¹ From the Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zürich, Switzerland (MBZ, RW, CZ, FR, and RFH); the Ministry of Health, Rabat, Morocco (NC); the Ministry of Health, Chaouen, Morocco (MS); and the Department of Endocrinology, University Children's Hospital, Zürich, Switzerland (TT).

Background: In many developing countries, children are at high risk for both goiter and anemia. In areas of subsistence farming in rural Africa, salt is one of the few regularly purchased food items and could be a good fortification vehicle for iodine and iron, provided that a stable yet bioavailable iron fortificant is used.

Objective: We tested the efficacy of salt dual-fortified with iodine and micronized ferric pyrophosphate for reducing the prevalence of iodine and iron deficiencies in children.

Design: In rural northern Morocco, we fortified local salt with 25 µg I (as potassium iodate)/g salt and 2 mg Fe (as micronized ferric pyrophosphate; mean particle size = 2.5 µm)/g salt. After storage and acceptability trials, we compared the efficacy of the dual-fortified salt (DFS) with that of iodized salt in a 10-mo, randomized, double-blind trial in iodine-deficient 6–15-y-old children (n = 158) with a high prevalence of anemia.

Results: After storage for 6 mo, there were no significant differences in iodine content or color lightness between the DFS and iodized salt. During the efficacy trial, the DFS provided 18 mg Fe/d; iron absorption was estimated to be 2%. After 10 mo of treatment in the DFS group, mean hemoglobin increased by 16 g/L (P < 0.01), iron status and body iron stores increased significantly (P < 0.01), and the prevalence of iron deficiency anemia decreased from 30% at baseline to 5% (P < 0.001). In both groups, urinary iodine (P < 0.001) and thyroid volume (P < 0.01) improved significantly from baseline.

Conclusion: A DFS containing iodine and micronized ferric pyrophosphate can be an effective fortification strategy in rural Africa.

Key Words: Iodine • iron • micronized ferric pyrophosphate • iodine deficiency • iron deficiency • dual fortification of salt • anemia • goiter • children

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