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ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Clinical Biochemistry, Institute of Medical and Veterinary Science, Adelaide, Australia (BECN, AGN, and PDO); the Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia (BECN, AGN, and MH); the Department of Medicine, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia (BECN, AGN, PDO, and MH); the Hanson Institute, Adelaide, Australia (BECN, AGN, and HAM); and the Department of Pathology, University of Adelaide, Adelaide, Australia(BECN).
Background: It is assumed that calcium absorption decreases with age, but this is not well documented. We report a study that addresses this issue.
Objective: The aim was to establish the extent and timing of any age-related change in calcium absorption in postmenopausal women.
Design: We measured radiocalcium absorption (
) in 262 healthy postmenopausal women aged 40-87 y. We also measured the serum vitamin D metabolites, parathyroid hormone (PTH), and other biochemical variables.
Results: Radiocalcium absorption decreased with age (P = 0.018); it was 28% lower in the 25 women aged >75 y than in the rest (P < 0.001). It was significantly related to serum 1,25-dihydroxyvitamin D [1,25(OH)2D] in the whole set and in both the younger and older subsets, but it was not related to either 25-dihydroxyvitamin D [25(OH)D] or PTH or to any other measured variable. No decrease in 1,25(OH)2D was seen with age to account for the decrease in calcium absorption, so radiocalcium absorption corrected for serum 1,25(OH)2D decreased significantly after age 75 y. On multivariate analysis, the serum 1,25(OH)2D concentration was a positive function of 25(OH)D (P < 0.001), albumin (P = 0.010), and PTH (P = 0.012) and a negative function of serum creatinine (P = 0.003). PTH was a negative function of calculated ionized calcium (P = 0.004) and 25(OH)D (P = 0.009) and a positive function of weight (P = 0.011) and age (P = 0.028).
Conclusions: A late age-related decrease in calcium absorption is seen in postmenopausal women in addition to the decline that occurs at menopause. This decrease could be due to a decline in either the active calcium transport or diffusion component of the calcium absorption system.
Key Words: Calcium absorption • age • 25-hydroxyvitamin D • 1,25-dihydroxyvitamin D • parathyroid hormone
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