| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Division of Epidemiology, School of Public Health, University of Minnesota (D-HL, ARF, LH, and DRJ); the Department of Preventive Medicine, School of Medicine, Kyungpook National University, Daegu, Korea (D-HL); the Department of Biochemistry, National University of Singapore (BH); and the Department of Nutrition, University of Oslo (DRJ)
Background: Vitamin C acts as a potent antioxidant; however, it can also be a prooxidant and glycate protein under certain circumstances in vitro. These observations led us to hypothesize that a high intake of vitamin C in diabetic persons might promote atherosclerosis.
Objective: The objective was to examine the relation between vitamin C intake and mortality from cardiovascular disease.
Design: We studied the relation between vitamin C intake and mortality from total cardiovascular disease (n = 281), coronary artery disease (n = 175), and stroke (n = 57) in 1923 postmenopausal women who reported being diabetic at baseline. Diet was assessed with a food-frequency questionnaire at baseline, and subjects initially free of coronary artery disease were prospectively followed for 15 y.
Results: After adjustment for cardiovascular disease risk factors, type of diabetes medication used, duration of diabetes, and intakes of folate, vitamin E, and ß-carotene, the adjusted relative risks of total cardiovascular disease mortality were 1.0, 0.97, 1.11, 1.47, and 1.84 (P for trend < 0.01) across quintiles of total vitamin C intake from food and supplements. Adjusted relative risks of coronary artery disease were 1.0, 0.81, 0.99, 1.26, and 1.91 (P for trend = 0.01) and of stroke were 1.0, 0.52, 1.23, 2.22, and 2.57 (P for trend < 0.01). When dietary and supplemental vitamin C were analyzed separately, only supplemental vitamin C showed a positive association with mortality endpoints. Vitamin C intake was unrelated to mortality from cardiovascular disease in the nondiabetic subjects at baseline.
Conclusion: A high vitamin C intake from supplements is associated with an increased risk of cardiovascular disease mortality in postmenopausal women with diabetes.
Key Words: Vitamin C • cardiovascular diseases • diabetes mellitus • iron
This article has been cited by other articles:
|
|
 |
|
  A. L Rogovik, S. Vohra, and R. D Goldman Safety Considerations and Potential Interactions of Vitamins: Should Vitamins Be Considered Drugs? Ann. Pharmacother., February 1, 2010; 44(2): 311 - 324. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R Jacobs Jr, M. D Gross, and L. C Tapsell Food synergy: an operational concept for understanding nutrition Am. J. Clinical Nutrition, May 1, 2009; 89(5): 1543S - 1548S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Park, L. Harnack, and D. R. Jacobs Jr. Trends in Dietary Supplement Use in a Cohort of Postmenopausal Women From Iowa Am. J. Epidemiol., April 1, 2009; 169(7): 887 - 892. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rees, J. Stevenson, and on behalf of the British Menopause Society Council Primary prevention of coronary heart disease in women Menopause Int, March 1, 2008; 14(1): 40 - 45. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Milman, S. Blum, C. Shapira, D. Aronson, R. Miller-Lotan, Y. Anbinder, J. Alshiek, L. Bennett, M. Kostenko, M. Landau, et al. Vitamin E Supplementation Reduces Cardiovascular Events in a Subgroup of Middle-Aged Individuals With Both Type 2 Diabetes Mellitus and the Haptoglobin 2-2 Genotype: A Prospective Double-Blinded Clinical Trial Arterioscler Thromb Vasc Biol, February 1, 2008; 28(2): 341 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Ceriello, L. Piconi, K. Esposito, and D. Giugliano Telmisartan Shows an Equivalent Effect of Vitamin C in Further Improving Endothelial Dysfunction After Glycemia Normalization in Type 1 Diabetes Diabetes Care, July 1, 2007; 30(7): 1694 - 1698. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Mejia-Rodriguez, D. Sotres-Alvarez, L. M. Neufeld, A. Garcia-Guerra, and C. Hotz Use of Nutritional Supplements among Mexican Women and the Estimated Impact on Dietary Intakes below the EAR and above the UL J. Am. Coll. Nutr., February 1, 2007; 26(1): 16 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Halliwell Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovasc Res, January 15, 2007; 73(2): 341 - 347. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D.-H. Lee, D. Y. Liu, D. R. Jacobs Jr., H.-R. Shin, K. Song, I.-K. Lee, B. Kim, and R. C. Hider Common Presence of Non-Transferrin-Bound Iron Among Patients With Type 2 Diabetes Diabetes Care, May 1, 2006; 29(5): 1090 - 1095. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Chen, R. J. Karne, G. Hall, U. Campia, J. A. Panza, R. O. Cannon III, Y. Wang, A. Katz, M. Levine, and M. J. Quon High-dose oral vitamin C partially replenishes vitamin C levels in patients with Type 2 diabetes and low vitamin C levels but does not improve endothelial dysfunction or insulin resistance Am J Physiol Heart Circ Physiol, January 1, 2006; 290(1): H137 - H145. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. N Hathcock, A. Azzi, J. Blumberg, T. Bray, A. Dickinson, B. Frei, I. Jialal, C. S Johnston, F. J Kelly, K. Kraemer, et al. Vitamins E and C are safe across a broad range of intakes Am. J. Clinical Nutrition, April 1, 2005; 81(4): 736 - 745. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Sell, K. M. Biemel, O. Reihl, M. O. Lederer, C. M. Strauch, and V. M. Monnier Glucosepane Is a Major Protein Cross-link of the Senescent Human Extracellular Matrix: RELATIONSHIP WITH DIABETES J. Biol. Chem., April 1, 2005; 280(13): 12310 - 12315. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
