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ORIGINAL RESEARCH COMMUNICATION |
1 From the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston (DM and EBR); the Divisions of Public Health Sciences and Clinical Research, Fred Hutchinson Cancer Research Center, Seattle (IBK, RLL, and GBM); and the Division of Cardiology, University of Washington, Seattle (WCL)
Background: trans Fatty acid (TFA) intake increases systemic inflammation in healthy persons. However, the effect in patients with established heart disease is unknown.
Objective: Our aim was to determine whether TFAs are associated with systemic inflammation in patients with established heart disease.
Design: Red blood cell membrane TFAs, a biomarker of dietary intake, and inflammatory marker concentrations were ascertained in 86 ambulatory patients with established heart failure. Associations between TFA levels and inflammatory markers were evaluated by linear regression.
Results: Mean (±SD) TFA levels were 1.8 ± 0.4% of membrane fatty acids (range: 0.7–2.9%). For each inflammatory marker, associations are presented as the absolute difference and percentage difference from the mean for each 1% higher membrane TFA level. After adjustment for age, sex, body mass index, diabetes, smoking, ejection fraction, New York Heart Association class, ischemic etiology, statin use, and serum glucose, TFA levels were positively associated with interleukin (IL) 1ß (difference from mean: 0.38 pg/mL; percentage difference from mean: 66%; P = 0.04), IL-1 receptor antagonist (4033 pg/mL; 297%; P = 0.006), IL-6 (9.5 pg/mL; 123%; P = 0.006), IL-10 (241 pg/mL; 183%; P = 0.02), tumor necrosis factor (TNF) 
(256 pg/mL; 249%; P = 0.02), TNF receptor 1 (537 pg/mL; 41%; P = 0.03), TNF receptor 2 (39 242 pg/mL; 247%; P = 0.001), monocyte chemoattractant protein 1 (117 pg/mL; 119%; P = 0.004), and brain natriuretic peptide (40 pg/mL; 57%; P = 0.04). Further adjustments for other patient characteristics did not significantly alter the results.
Conclusion: TFAs are strongly associated with systemic inflammation in patients with heart disease, which suggests that attention to TFA intake may be important for secondary prevention efforts.
Key Words: Inflammation • trans fatty acids • heart failure • diet tumor necrosis factor • interleukin
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