| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Department of Psychiatry (TT, JH, and HV), the Research Institute of Public Health (SV, AR, KN, and JTS), and the Department of Public Health and General Practice (JTS), University of Kuopio, Kuopio, Finland; the National Public Health Institute, Helsinki (GA); the Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI (GAK); and the Inner Savo Health Centre, Suonenjoki, Finland (JTS)
Background: Results of studies of the association between blood concentrations of homocysteine and depression in general populations and among psychiatric patients are inconsistent.
Objective: The objective was to study the association between depression and serum concentrations of total homocysteine (tHcy).
Design: A cross-sectional study of a sample of 924 men aged 46–64 y was conducted as a part of the Kuopio Ischaemic Heart Disease Risk Factor Study. Those who had a history of psychiatric disorder (6.0%) were excluded. Depressive symptoms were assessed with the 18-item Human Population Laboratory Depression Scale. Those who scored 
5 at baseline or at the 4-y follow-up were considered to have a tendency toward depression.
Results: The participants were ranked according to their blood tHcy concentration and divided into tertiles. Those in the upper tertile for serum tHcy had a more than twofold (odds ratio: 2.30; 95% CI: 1.35, 3.90; P = 0.002) higher risk of being depressed than did those in the lowest tertile for serum tHcy. The results remained significant after adjustment for the month of study, history of ischemic heart disease, smoking habits, alcohol consumption, marital status, education, and socioeconomic status in adulthood (odds ratio: 2.23; 95% CI: 1.30, 3.83; P = 0.004).
Conclusion: High serum concentrations of tHcy may be associated with depression in middle-aged men.
Key Words: Depression • homocysteine • folate • Kuopio Ischaemic Heart Disease Risk Factor Study
This article has been cited by other articles:
|
|
 |
|
  P. G. Surtees, N. W.J. Wainwright, R. N. Luben, N. J. Wareham, S. A. Bingham, and K.-T. Khaw Depression and Ischemic Heart Disease Mortality: Evidence From the EPIC-Norfolk United Kingdom Prospective Cohort Study Am J Psychiatry, April 1, 2008; 165(4): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-M. Kim, R. Stewart, S.-W. Kim, S.-J. Yang, I.-S. Shin, and J.-S. Yoon Predictive value of folate, vitamin B12 and homocysteine levels in late-life depression The British Journal of Psychiatry, April 1, 2008; 192(4): 268 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. G. Surtees, N.W.J. Wainwright, R. N. Luben, N. J. Wareham, S. A. Bingham, and K.-T Khaw Psychological distress, major depressive disorder, and risk of stroke Neurology, March 4, 2008; 70(10): 788 - 794. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Soumare, A. Elbaz, V. Ducros, B. Tavernier, A. Alperovitch, and C. Tzourio Cross-sectional association between homocysteine and motor function in the elderly. Neurology, September 26, 2006; 67(6): 985 - 990. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Refsum, E. Nurk, A. D. Smith, P. M. Ueland, C. G. Gjesdal, I. Bjelland, A. Tverdal, G. S. Tell, O. Nygard, and S. E. Vollset The Hordaland Homocysteine Study: A Community-Based Study of Homocysteine, Its Determinants, and Associations with Disease J. Nutr., June 1, 2006; 136(6): 1731S - 1740S. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Schwab, A. Torronen, E. Meririnne, M. Saarinen, G. Alfthan, A. Aro, and M. Uusitupa Orally Administered Betaine Has an Acute and Dose-Dependent Effect on Serum Betaine and Plasma Homocysteine Concentrations in Healthy Humans J. Nutr., January 1, 2006; 136(1): 34 - 38. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
