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ORIGINAL RESEARCH COMMUNICATION |
1 From the Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain (HO, PC, DG-C, and MAL); the Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Alcalá de Henares, Spain (MAL); Unidad de Lípidos, Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Spain (CG, MB, and MdO); and the Departamento de Medicina Preventiva y Salud Pública, Universidad Autónoma de Madrid, Spain (FR-A)
Background:Apolipoprotein (apo) E is a major determinant of plasma lipid concentrations, which in turn influence the plasma concentrations of various fat-soluble vitamins.
Objective:We aimed to analyze the effect of APOE genotype on fat-soluble antioxidant concentrations in children.
Design:A total of 926 healthy boys and girls aged 6–8 y were selected from 4 cities in Spain. APOE genotyping was carried out, and plasma concentrations of lipids, apolipoproteins, and lipid-soluble antioxidants were measured.
Results:Plasma lipid concentrations were strongly influenced by APOE genotype. The mean plasma concentration of 
-tocopherol was 21.3 µmol/L, which is one of the highest values ever reported for a population of children. Although plasma concentrations of -tocopherol, 
-tocopherol, lycopene, and -carotene varied significantly between subjects with different APOE genotypes, most of these differences disappeared after adjustment for lipoprotein-related covariates. Nevertheless, tocopherol concentrations remained elevated in individuals with the E2/2 genotype. Multivariate regression analysis showed interactions of APOE genotype with triacylglycerol and apo B in determining -tocopherol concentrations. When subjects were stratified according to major apo E groups, apo B appeared to be the most important predictor of -tocopherol concentrations in all groups, whereas triacylglycerol was identified only in carriers of the E2 allele.
Conclusions:The association between APOE genotype and lipophilic antioxidant concentrations is dependent mainly on the effect of the polymorphism on lipoprotein concentrations. However, triacylglycerol plays a role in determining the variability of -tocopherol concentrations in E2 carriers only. This suggests that the -tocopherol content in each lipoprotein class varies according to APOE genotype.
Key Words: Apolipoprotein E • tocopherols • carotenoids • antioxidants • lipoproteins • children
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