| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
1 From the Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA (TP, GSH, and EBR); the Channing Laboratory, Harvard Medical School and Brigham & Women’s Hospital, Boston, MA (EBR); the Department of Laboratory Medicine, Children’s Hospital and the Department of Pathology, Harvard Medical School, Boston, MA (NR); the Department of Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany (TP); and the Department of Epidemiology, Merck Research Laboratories, West Point, PA (CJG).
Background: Adiponectin, an adipocyte-derived peptide, improves insulin sensitivity, has antiinflammatory and antiatherogenic effects, and is associated with a lower risk of ischemic heart disease (IHD) and type 2 diabetes. However, little is known about dietary predictors of plasma adiponectin concentrations in humans.
Objective: Our objective was to examine cross-sectionally the association between dietary factors and plasma adiponectin in men.
Design: Our study included 532 male participants of the Health Professionals Follow-Up Study who were selected as control subjects for an investigation of biological predictors of IHD. Diet, lifestyle, and anthropometric data were assessed by questionnaires.
Results: After multivariable adjustment, adiponectin was significantly inversely related to glycemic load (–1.3 mg/L per 1-SD increase; P = 0.02) and tended to be positively associated with total fat intake (0.7 mg/L per 0.5% of energy from fat instead of carbohydrates; P = 0.06). We also found a significant nonlinear association between plasma adiponectin concentrations and alcohol intake (P for quadratic trend = 0.01). Thus, whereas nondrinkers had mean plasma adiponectin concentrations of 16.48 mg/L, those who consumed 0.1–4.9, 5.0–14.9, 15.0–29.9, or 
30 g alcohol/d had mean concentrations of 16.79 (P = 0.77 compared with nondrinkers), 18.97 (P = 0.02), 19.11 (P = 0.01), and 18.39 (P = 0.10) mg/L, respectively.
Conclusions: Moderate alcohol intake is associated with higher adiponectin concentrations, whereas a carbohydrate-rich diet with a high glycemic load is associated with lower adiponectin concentrations in men with no history of cardiovascular disease. Although the strength of these associations was modest, our observations highlight the hypothesis that dietary factors may modulate plasma adiponectin concentrations—a potential mediator related to a reduced IHD risk.
Key Words: Obesity • nutrition • risk factors • cardiovascular disease • ischemic heart disease
This article has been cited by other articles:
|
|
 |
|
  R. B. Goldberg Cytokine and Cytokine-Like Inflammation Markers, Endothelial Dysfunction, and Imbalanced Coagulation in Development of Diabetes and Its Complications J. Clin. Endocrinol. Metab., September 1, 2009; 94(9): 3171 - 3182. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. A. Mekary, W. C. Willett, F. B. Hu, and E. L. Ding Isotemporal Substitution Paradigm for Physical Activity Epidemiology and Weight Change Am. J. Epidemiol., August 15, 2009; 170(4): 519 - 527. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. K. Chung, J. S. Chae, Y. J. Hyun, J. K. Paik, J. Y. Kim, Y. Jang, H. M. Kwon, Y. D. Song, H. C. Lee, and J. H. Lee Influence of Adiponectin Gene Polymorphisms on Adiponectin Level and Insulin Resistance Index in Response to Dietary Intervention in Overweight-Obese Patients With Impaired Fasting Glucose or Newly Diagnosed Type 2 Diabetes Diabetes Care, April 1, 2009; 32(4): 552 - 558. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cassidy, P. Skidmore, E. B. Rimm, A. Welch, S. Fairweather-Tait, J. Skinner, K. Burling, J. B. Richards, T. D. Spector, and A. J. MacGregor Plasma Adiponectin Concentrations Are Associated with Body Composition and Plant-Based Dietary Factors in Female Twins J. Nutr., February 1, 2009; 139(2): 353 - 358. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yannakoulia, N. Yiannakouris, L. Melistas, E. Fappa, N. Vidra, M. D Kontogianni, and C. S Mantzoros Dietary factors associated with plasma high molecular weight and total adiponectin levels in apparently healthy women Eur. J. Endocrinol., October 1, 2008; 159(4): R5 - R10. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W.J. Beulens, E. B. Rimm, F. B. Hu, H. F.J. Hendriks, and K. J. Mukamal Alcohol Consumption, Mediating Biomarkers, and Risk of Type 2 Diabetes Among Middle-Aged Women Diabetes Care, October 1, 2008; 31(10): 2050 - 2055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Perez-Martinez, J. Lopez-Miranda, C. Cruz-Teno, J. Delgado-Lista, Y. Jimenez-Gomez, J. M. Fernandez, M. J. Gomez, C. Marin, F. Perez-Jimenez, and J. M. Ordovas Adiponectin Gene Variants Are Associated with Insulin Sensitivity in Response to Dietary Fat Consumption in Caucasian Men J. Nutr., September 1, 2008; 138(9): 1609 - 1614. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. de Ferranti and D. Mozaffarian The Perfect Storm: Obesity, Adipocyte Dysfunction, and Metabolic Consequences Clin. Chem., June 1, 2008; 54(6): 945 - 955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Kratz, M. M Swarbrick, H. S Callahan, C. C Matthys, P. J Havel, and D. S Weigle Effect of dietary n-3 polyunsaturated fatty acids on plasma total and high-molecular-weight adiponectin concentrations in overweight to moderately obese men and women Am. J. Clinical Nutrition, February 1, 2008; 87(2): 347 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. Beck and S. Richy Differential long-term dietary regulation of adipokines, ghrelin, or corticosterone: impact on adiposity J. Endocrinol., January 1, 2008; 196(1): 171 - 179. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Barb, C. J Williams, A. K Neuwirth, and C. S Mantzoros Adiponectin in relation to malignancies: a review of existing basic research and clinical evidence Am. J. Clinical Nutrition, September 1, 2007; 86(3): 858S - 866S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Y. Bang, J. L. Saver, B. Ovbiagele, Y. J. Choi, S. R. Yoon, and K. H. Lee Adiponectin levels in patients with intracranial atherosclerosis Neurology, May 29, 2007; 68(22): 1931 - 1937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. E. Cust, R. Kaaks, C. Friedenreich, F. Bonnet, M. Laville, A. Lukanova, S. Rinaldi, L. Dossus, N. Slimani, E. Lundin, et al. Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women J. Clin. Endocrinol. Metab., January 1, 2007; 92(1): 255 - 263. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. J. Hernandez-Morante, F. Milagro, J. A. Gabaldon, J. A. Martinez, S. Zamora, and M. Garaulet Effect of DHEA-sulfate on adiponectin gene expression in adipose tissue from different fat depots in morbidly obese humans. Eur. J. Endocrinol., October 1, 2006; 155(4): 593 - 600. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Qi, J. B. Meigs, S. Liu, J. E. Manson, C. Mantzoros, and F. B. Hu Dietary Fibers and Glycemic Load, Obesity, and Plasma Adiponectin Levels in Women With Type 2 Diabetes Diabetes Care, July 1, 2006; 29(7): 1501 - 1505. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Pischon and E. B. Rimm Adiponectin: a promising marker for cardiovascular disease. Clin. Chem., May 1, 2006; 52(5): 797 - 799. [Full Text] [PDF]
|
|
|
|
|
|
S. E Kasim-Karakas, A. Tsodikov, U. Singh, and I. Jialal Responses of inflammatory markers to a low-fat, high-carbohydrate diet: effects of energy intake. Am. J. Clinical Nutrition, April 1, 2006; 83(4): 774 - 779. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K Kabagambe, A. Baylin, E. Ruiz-Narvaez, E. B Rimm, and H. Campos Alcohol intake, drinking patterns, and risk of nonfatal acute myocardial infarction in Costa Rica Am. J. Clinical Nutrition, December 1, 2005; 82(6): 1336 - 1345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. J. Mukamal, M. K. Jensen, M. Gronbaek, M. J. Stampfer, J. E. Manson, T. Pischon, and E. B. Rimm Drinking Frequency, Mediating Biomarkers, and Risk of Myocardial Infarction in Women and Men Circulation, September 6, 2005; 112(10): 1406 - 1413. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
