HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Larsson, S. C Articles by Wolk, A. Search for Related Content PubMed PubMed Citation Articles by Larsson, S. C Articles by Wolk, A. Agricola Articles by Larsson, S. C Articles by Wolk, A.

Association of diet with serum insulin-like growth factor I in middle-aged and elderly men^1,2,3

From the Division of Nutritional Epidemiology, The National Institute of Environmental Medicine (SCL and AW) and the Departments of Medicine (KW) and Molecular Medicine (KB), Unit of Endocrinology and Diabetes, Karolinska Institutet, Stockholm

Background: Insulin-like growth factor I (IGF-I) has been implicated in several chronic diseases, including cancer, heart disease, and osteoporosis.

Objective: Our aim was to assess whether intakes of total energy, alcohol, vitamins, minerals, and foods rich in protein and minerals (including red meat, fish and seafood, poultry, and milk) are associated with serum IGF-I concentrations in middle-aged and elderly men.

Design: We measured serum IGF-I concentrations in 226 free-living healthy men aged 42–76 y. The average of fourteen 24-h dietary telephone interviews performed over 1 y was used to estimate long-term dietary intake.

Results: We observed statistically significant positive associations between intakes of protein (P for trend = 0.001) and zinc (P fortrend = 0.002) and serum IGF-I concentrations after adjusting for age. The difference in mean IGF-I concentrations for the highest compared with the lowest quintile of intake was 17% (162 µg/L compared with 139 µg/L) for protein and 16% (166 µg/L compared with 143 µg/L) for zinc. Consumption of red meat (P for trend = 0.05) and fish and seafood (P for trend = 0.07) was modestly positively associated with IGF-I concentrations. Other dietary factors were not associated with IGF-I concentrations.

Conclusion: In this population of healthy well-nourished men, greater dietary intakes of protein, zinc, red meat, and fish and seafood were associated with higher IGF-I concentrations.

Key Words: Diet • insulin-like growth factor I • IGF-I • fish • minerals • nutrients • protein • red meat • zinc

This article has been cited by other articles:

				F. L Crowe, T. J Key, P. N Appleby, R. C Travis, K. Overvad, M. U Jakobsen, N. F Johnsen, A. Tjonneland, J. Linseisen, S. Rohrmann, et al. Dietary fat intake and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1405 - 1413. [Abstract] [Full Text] [PDF]

				R. P Heaney and D. K Layman Amount and type of protein influences bone health Am. J. Clinical Nutrition, May 1, 2008; 87(5): 1567S - 1570S. [Abstract] [Full Text] [PDF]

				Y. Manios, G. Moschonis, G. Trovas, and G. P Lyritis Changes in biochemical indexes of bone metabolism and bone mineral density after a 12-mo dietary intervention program: the Postmenopausal Health Study Am. J. Clinical Nutrition, September 1, 2007; 86(3): 781 - 789. [Abstract] [Full Text] [PDF]