HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Scholl, T. O Articles by Stein, T P. Search for Related Content PubMed PubMed Citation Articles by Scholl, T. O Articles by Stein, T P. Agricola Articles by Scholl, T. O Articles by Stein, T P.

Oxidative stress, diet, and the etiology of preeclampsia^1,2,3

¹ From the Department of Obstetrics and Gynecology (TOS and XC) and the Department of Surgery (ML, MS, and TPS), University of Medicine and Dentistry of New Jersey–School of Osteopathic Medicine, Stratford, NJ

Background: A current theory holds that oxidative stress, ie, an imbalance between maternal prooxidants and antioxidants, is a component of preeclampsia. It is uncertain whether such an imbalance occurs before clinical recognition of the syndrome or whether it is related to diet.

Objective: We measured urinary excretion of the isoprostane 8-iso-prostaglandin F₂, which is an indicator of oxidative damage to lipids, and the total antioxidant power, which is a global measure of antioxidant status, at the entry to prenatal care. We also examined the relation of these indexes to diet during pregnancy.

Design: A cohort of 307 gravidae from Camden, NJ, was studied from entry to prenatal care (at 15.0 ± 0.49 wk gestation). Measures of the maternal diet were obtained by 24-h recall.

Results: Risk of preeclampsia was increased 5-fold with higher urinary isoprostane excretion and decreased 3-fold with higher total antioxidant power. Over the course of pregnancy, there were significant trends for an association of higher isoprostane excretion with increased consumption of energy-adjusted fat, polyunsaturated fat, and polyunsaturated fatty acids (n–3, n–6, and linoleic and linolenic fatty acids), whereas total antioxidant power was not related to diet.

Conclusions: Increased urinary excretion of isoprostane and decreased antioxidant production is an imbalance that is consistent with oxidative stress, and it precedes clinical recognition of preeclampsia. The maternal diet is an underlying factor that provides an environment for free radical generation.

Key Words: Preeclampsia • diet • isoprostanes • total antioxidant capacity • total antioxidant power • oxidative stress • antioxidants • maternal nutrition • pregnancy

This article has been cited by other articles:

				X. Chen and T. O. Scholl Association of Elevated Free Fatty Acids During Late Pregnancy With Preterm Delivery Obstet. Gynecol., August 1, 2008; 112(2): 297 - 303. [Abstract] [Full Text] [PDF]

				J. V. Ilekis, U. M. Reddy, and J. M. Roberts Review Article: Preeclampsia A Pressing Problem: An Executive Summary of a National Institute of Child Health and Human Development Workshop Reproductive Sciences, September 1, 2007; 14(6): 508 - 523. [Abstract] [PDF]

				T. O Scholl, X. Chen, M. Sims, and T P. Stein Vitamin E: maternal concentrations are associated with fetal growth Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1442 - 1448. [Abstract] [Full Text] [PDF]

				E. Jauniaux, L. Poston, and G. J. Burton Placental-related diseases of pregnancy: involvement of oxidative stress and implications in human evolution Hum. Reprod. Update, November 1, 2006; 12(6): 747 - 755. [Abstract] [Full Text] [PDF]