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ORIGINAL RESEARCH COMMUNICATION |
T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men1,2,3
1 From the Departments of Nutrition (CZ, RL-R, EBR, DJH, and FBH) and Epidemiology (EBR and FBH), Harvard School of Public Health, Boston, MA; the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (RL-R, EBR, DJH, and FBH); and the Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA (NR)
BACKGROUND:: Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (–514C
T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations.
OBJECTIVE:: We examined the association between this polymorphism and plasma HDL-cholesterol concentrations and evaluated whether this association was modified by adiposity and dietary fat intake.
DESIGN:: We followed men aged 40–75 y who participated in the Health Professionals Follow-Up Study in 1986. Among 18 159 men who returned blood samples by 1994, 780 had confirmed type 2 diabetes at blood drawing or during follow-up to 1998 and were free of cardiovascular disease at blood drawing.
RESULTS:: After adjustment for age, smoking, alcohol consumption, fasting status, glycated hemoglobin concentration, physical activity, and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T or T/T genotype than in those with the C/C genotype (adjusted 
: 40.9 and 38.8 mg/dL, respectively; P = 0.01). We observed significant LIPC –514 polymorphism x body mass index and LIPC –514 polymorphism x saturated fat intake interactions for HDL-cholesterol concentrations (P = 0.003 for both). The T allele was associated with higher HDL-cholesterol concentrations only in men who were not overweight or who had higher saturated fat intake.
CONCLUSION:: Our study suggests that the effects of –514CT of the LIPC gene on HDL concentrations were modified by saturated fat intake and obesity.
Key Words: Interactions • –514CT polymorphism • hepatic lipase gene • dietary fat • body mass index • HDL • type 2 diabetes • Health Professionals Follow-Up Study
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