| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
ORIGINAL RESEARCH COMMUNICATION |
T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men1,2,3
1 From the Departments of Nutrition (CZ, RL-R, EBR, DJH, and FBH) and Epidemiology (EBR and FBH), Harvard School of Public Health, Boston, MA; the Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (RL-R, EBR, DJH, and FBH); and the Department of Laboratory Medicine, Children's Hospital and Harvard Medical School, Boston, MA (NR)
BACKGROUND:: Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (–514C
T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations.
OBJECTIVE:: We examined the association between this polymorphism and plasma HDL-cholesterol concentrations and evaluated whether this association was modified by adiposity and dietary fat intake.
DESIGN:: We followed men aged 40–75 y who participated in the Health Professionals Follow-Up Study in 1986. Among 18 159 men who returned blood samples by 1994, 780 had confirmed type 2 diabetes at blood drawing or during follow-up to 1998 and were free of cardiovascular disease at blood drawing.
RESULTS:: After adjustment for age, smoking, alcohol consumption, fasting status, glycated hemoglobin concentration, physical activity, and body mass index, HDL-cholesterol concentrations were significantly higher in men with the C/T or T/T genotype than in those with the C/C genotype (adjusted 
: 40.9 and 38.8 mg/dL, respectively; P = 0.01). We observed significant LIPC –514 polymorphism x body mass index and LIPC –514 polymorphism x saturated fat intake interactions for HDL-cholesterol concentrations (P = 0.003 for both). The T allele was associated with higher HDL-cholesterol concentrations only in men who were not overweight or who had higher saturated fat intake.
CONCLUSION:: Our study suggests that the effects of –514CT of the LIPC gene on HDL concentrations were modified by saturated fat intake and obesity.
Key Words: Interactions • –514CT polymorphism • hepatic lipase gene • dietary fat • body mass index • HDL • type 2 diabetes • Health Professionals Follow-Up Study
This article has been cited by other articles:
|
|
 |
|
  N. Grarup, C. H. Andreasen, M. K. Andersen, A. Albrechtsen, A. Sandbaek, T. Lauritzen, K. Borch-Johnsen, T. Jorgensen, O. Schmitz, T. Hansen, et al. The -250G>A Promoter Variant in Hepatic Lipase Associates with Elevated Fasting Serum High-Density Lipoprotein Cholesterol Modulated by Interaction with Physical Activity in a Study of 16,156 Danish Subjects J. Clin. Endocrinol. Metab., June 1, 2008; 93(6): 2294 - 2299. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Y Li, C. Zhang, F. W Asselbergs, L. Qi, E. Rimm, D. J Hunter, and F. B Hu Interaction between dietary fat intake and the cholesterol ester transfer protein TaqIB polymorphism in relation to HDL-cholesterol concentrations among US diabetic men Am. J. Clinical Nutrition, November 1, 2007; 86(5): 1524 - 1529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. S Fisler and C. H Warden Dietary fat and genotype: toward individualized prescriptions for lifestyle changes Am. J. Clinical Nutrition, June 1, 2005; 81(6): 1255 - 1256. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
