HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Feillet-Coudray, C. Articles by Coudray, C. Search for Related Content PubMed PubMed Citation Articles by Feillet-Coudray, C. Articles by Coudray, C. Agricola Articles by Feillet-Coudray, C. Articles by Coudray, C.

Long-term moderate zinc supplementation increases exchangeable zinc pool masses in late-middle-aged men: the Zenith Study^1,2,3

¹ From the Centre de Recherche en Nutrition Humaine d'Auvergne, Unité Maladies Métaboliques et Micronutriments, INRA, St Genès Champanelle, France (CF-C, NM, MR, JCT, AM, and CC); the Laboratoire de Nutrition Humaine, Clermont-Ferrand, France (MB-B); the Laboratoire de Biologie du Stress Oxydant, UFR de Pharmacie, La Tronche, France (MA); and the Department of Food and Nutritional Sciences, University College, Cork, Ireland (KDC)

Background: Zinc supplementation may be beneficial for health. Assessing exchangeable zinc pools may be a useful approach to evaluate zinc status.

Objective: We evaluated the effects of long-term supplementation with 2 moderate doses of zinc on the mass of exchangeable zinc pools.

Design: Three groups of healthy, late-middle-aged men (n = 16 per group) participated in a stable-isotope zinc kinetic study after 6 mo of daily supplementation with 0 (placebo), 15, or 30 mg Zn. At the end of the supplementation period, each subject received an intravenous injection of 0.89 mg ⁷⁰Zn, and the plasma zinc disappearance curve was monitored for the next 10 d. Two approaches were used to determine the characteristics of the exchangeable zinc pools: 1) formal 3-compartmental modeling and 2) a simplified determination of the total mass of the rapidly exchangeable zinc pool (EZP).

Results: In the placebo group, the exchangeable zinc pool masses for the 3 considered pools were as follows: 2.15, 12.7, and 100.5 mg Zn. The rapidly exchangeable zinc pool mass in the placebo group was 143 mg Zn. Zinc supplementation significantly increased the exchangeable zinc pool masses regardless of the approach used to determine these pools. In addition, these data confirm that exchangeable zinc pool masses correlate positively with total zinc intake and negatively with subject age and do not correlate with plasma zinc concentrations.

Conclusion: Our data show that long-term supplementation with 2 moderate doses of zinc is an efficient way to increase exchangeable zinc pool masses in late-middle-aged men.

Key Words: Exchangeable zinc pools • kinetic modeling • stable isotope • zinc supplementation • late-middle-aged subjects • zinc status

This article has been cited by other articles:

				N. F Krebs, J. L Westcott, D. J Rodden, K. W Ferguson, L. V Miller, and K M. Hambidge Exchangeable zinc pool size at birth is smaller in small-for-gestational-age than in appropriate-for-gestational-age preterm infants Am. J. Clinical Nutrition, December 1, 2006; 84(6): 1340 - 1343. [Abstract] [Full Text] [PDF]