HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Blackburn, G. L Search for Related Content PubMed PubMed Citation Articles by Blackburn, G. L Agricola Articles by Blackburn, G. L

Solutions in weight control: lessons from gastric surgery ^1,2,3,4

¹ From the Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

ABSTRACT

Surgical therapy is currently the only proven way to achieve significant long-term weight loss, improve obesity-related comorbidities, reduce the risk of premature death, and improve quality of life in a large proportion of treated individuals. Roux-en-Y gastric bypass, the most widely performed procedure in the United States, is known to achieve permanent (>14 y of follow-up) and significant (>50% of excess body weight) weight loss in >90% of patients who undergo the operation. Gastric bypass procedures induce physiologic and neuroendocrine changes that appear to affect the weight regulatory centers in the brain. Researchers have begun to explore the molecular pathways responsible for these outcomes. Identifying the differences between surgical and nonsurgical treatments will eventually lead to new therapeutic options.

Key Words: Weight loss surgery • WLS • bariatric surgery • gastric bypass • gastroplasty • laparoscopic adjustable gastric banding

This article has been cited by other articles:

				R. K Simmons and N. J Wareham Commentary: Obesity is not a newly recognized public health problem--a commentary of Breslow's 1952 paper on 'public health aspects of weight control' Int. J. Epidemiol., February 1, 2006; 35(1): 14 - 16. [Full Text] [PDF]

				G. L Blackburn and W A. Walker Science-based solutions to obesity: what are the roles of academia, government, industry, and health care? Am. J. Clinical Nutrition, July 1, 2005; 82(1): 207S - 210S. [Abstract] [Full Text] [PDF]